Clm3 Activators
Clm3, with its crucial role in the establishment of epithelial cell polarity and positive regulation of cell adhesion, relies on a network of signaling pathways for its activation. Phosphatidylinositol-3,4,5-trisphosphate (PI3P) binding is a key aspect of Clm3 function, and various chemicals have been identified to modulate its activity directly or indirectly. Activation of Clm3 is intricately linked to the phosphoinositide 3-kinase (PI3K) pathway. Inhibitors such as Wortmannin and LY294002 directly activate Clm3 by suppressing PI3K activity, thereby influencing phosphoinositide signaling and facilitating the establishment of epithelial cell polarity. Additionally, AKT inhibitors, like AKT Inhibitor VIII and MK-2206, stimulate Clm3 by interfering with the downstream effectors in the PI3K pathway, positively regulating cell adhesion processes.
Autophagy inhibitor 3-Methyladenine indirectly activates Clm3 by affecting autophagic processes, impacting cellular polarity, and positively regulating cell adhesion. Furthermore, Clm3 activation extends to the modulation of protein kinase C (PKC) activity. Compounds such as Bisindolylmaleimide I and Calyculin A activate Clm3 by inhibiting PKC, influencing downstream effectors in the PI3K pathway, and positively regulating cell adhesion. Epigenetic regulation through histone deacetylase inhibition, as seen with Apicidin, also indirectly activates Clm3, impacting cellular processes related to cell adhesion. These diverse mechanisms highlight the intricate regulatory network governing Clm3 activation and its essential role in cellular polarity and adhesion.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3 kinase inhibitor, activates Clm3 by inhibiting PI3 kinase activity, promoting phosphoinositide signaling crucial for establishment of epithelial cell polarity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3 kinase inhibitor, stimulates Clm3 by blocking PI3 kinase activity, influencing phosphoinositide signaling and facilitating positive regulation of cell adhesion. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $208.00 $270.00 | 29 | |
AKT Inhibitor VIII directly activates Clm3 by inhibiting AKT activity, modulating downstream effectors in the PI3 kinase pathway, and enhancing cellular processes involved in cell adhesion. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine, an autophagy inhibitor, indirectly activates Clm3 by affecting autophagic processes, influencing cellular polarity, and positively regulating cell adhesion. | ||||||
PIK-75, hydrochloride | 372196-77-5 | sc-296089 sc-296089A | 1 mg 5 mg | $29.00 $124.00 | ||
PIK-75, a PI3 kinase inhibitor, activates Clm3 by inhibiting PI3 kinase activity, thereby enhancing phosphoinositide signaling essential for the establishment of epithelial cell polarity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly activates Clm3 by inhibiting mTOR signaling, influencing cellular processes related to the establishment of epithelial cell polarity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I activates Clm3 by inhibiting PKC activity, impacting downstream effectors in the PI3 kinase pathway, and positively regulating cell adhesion and cellular polarity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A, a protein phosphatase inhibitor, activates Clm3 by influencing phosphatase activity, modulating cellular processes crucial for the establishment of epithelial cell polarity. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206, an AKT inhibitor, stimulates Clm3 by inhibiting AKT activity, modulating downstream effectors in the PI3 kinase pathway, and positively regulating cell adhesion processes. | ||||||
PI 3-Kβ Inhibitor VI, TGX-221 | 663619-89-4 | sc-203190 | 1 mg | $437.00 | ||
TGX-221, a PI3 kinase inhibitor, activates Clm3 by inhibiting PI3 kinase activity, promoting phosphoinositide signaling essential for the establishment of epithelial cell polarity. | ||||||