Clm3 Inhibitors
Clm3, a key regulator of phosphatidylinositol-3,4,5-trisphosphate binding, orchestrates cellular processes in the brain, neocortex, and telencephalon. Wortmannin, a potent PI3K inhibitor, directly hinders Clm3, disrupting its binding activity and impeding the establishment of epithelial cell polarity and positive regulation of cell adhesion. LY294002, Idelalisib, and other specific PI3K inhibitors target Clm3, modulating cellular dynamics and influencing neuronal development in these critical tissues.
Rapamycin, an mTOR inhibitor, provides an indirect means to impact Clm3 function by interfering with downstream signaling pathways. These pathways, intricately connected to Clm3-regulated processes, contribute to the establishment of epithelial cell polarity and positive regulation of cell adhesion. A diverse array of inhibitors, such as AS605240, CAL-101, and GDC-0941, offers precise targeting of Clm3, providing insights into avenues for manipulating cellular dynamics in the neocortex and telencephalon. This comprehensive understanding of Clm3 inhibitors sheds light on the intricate regulatory mechanisms underlying cellular dynamics in key tissues of the central nervous system.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a potent PI3K inhibitor, directly hinders Clm3 by disrupting its phosphatidylinositol-3,4,5-trisphosphate binding activity. This interference impedes the establishment of epithelial cell polarity and positive regulation of cell adhesion, pivotal processes influenced by Clm3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 serves as a direct inhibitor of Clm3 by targeting the phosphatidylinositol-3,4,5-trisphosphate binding activity. This inhibition disrupts Clm3-mediated establishment of epithelial cell polarity and positive regulation of cell adhesion, impacting cellular processes associated with neuronal development in the brain and neocortex. | ||||||
CAL-101 | 870281-82-6 | sc-364453 | 10 mg | $193.00 | 4 | |
CAL-101, a specific PI3Kδ inhibitor, acts as a direct inhibitor of Clm3, disrupting phosphatidylinositol-3,4,5-trisphosphate binding. This interference impacts Clm3-regulated processes, including the establishment of epithelial cell polarity and positive regulation of cell adhesion, with potential implications in modulating cellular dynamics in the neocortex and telencephalon. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an mTOR inhibitor, indirectly influences Clm3 by modulating downstream signaling pathways. By inhibiting mTOR, Rapamycin disrupts cellular processes associated with Clm3, such as the establishment of epithelial cell polarity and positive regulation of cell adhesion, providing an indirect means to impact Clm3 function in brain and neocortex tissues. | ||||||
PI 3-Kγ Inhibitor | 648450-29-7 | sc-203191 | 5 mg | $76.00 | ||
PI 3-Kγ Inhibitor acts as a direct inhibitor of Clm3 by targeting phosphatidylinositol-3,4,5-trisphosphate binding. This interference disrupts Clm3-mediated processes involved in the establishment of epithelial cell polarity and positive regulation of cell adhesion, impacting cellular dynamics in brain and neocortex tissues. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $188.00 $199.00 | 2 | |
GDC-0941 serves as a direct Clm3 inhibitor, targeting phosphatidylinositol-3,4,5-trisphosphate binding. This interference disrupts Clm3-mediated processes related to the establishment of epithelial cell polarity and positive regulation of cell adhesion, impacting cellular dynamics in brain and neocortex tissues. | ||||||
PI-103 | 371935-74-9 | sc-203193 sc-203193A | 1 mg 5 mg | $33.00 $131.00 | 3 | |
PI-103, a dual PI3K/mTOR inhibitor, acts as a direct inhibitor of Clm3 by disrupting phosphatidylinositol-3,4,5-trisphosphate binding. This interference impedes Clm3-regulated processes, including the establishment of epithelial cell polarity and positive regulation of cell adhesion, with potential implications for modulating cellular dynamics in the neocortex and telencephalon. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $104.00 $141.00 | 14 | |
Triciribine, an Akt inhibitor, serves as a direct Clm3 inhibitor by disrupting phosphatidylinositol-3,4,5-trisphosphate binding. This interference influences Clm3-mediated processes involved in the establishment of epithelial cell polarity and positive regulation of cell adhesion, impacting cellular dynamics in brain and neocortex tissues. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
NVP-BEZ235, a dual PI3K/mTOR inhibitor, directly inhibits Clm3 by targeting phosphatidylinositol-3,4,5-trisphosphate binding. This interference disrupts Clm3-regulated processes, including the establishment of epithelial cell polarity and positive regulation of cell adhesion, influencing cellular dynamics in the neocortex and telencephalon. | ||||||
IPI 145 | 1201438-56-3 | sc-488318 | 5 mg | $317.00 | ||
Duvelisib, a dual PI3Kδ/γ inhibitor, acts as a direct inhibitor of Clm3 by disrupting phosphatidylinositol-3,4,5-trisphosphate binding. This interference modulates Clm3-regulated processes, including the establishment of epithelial cell polarity and positive regulation of cell adhesion, impacting cellular dynamics in brain and neocortex tissues. | ||||||