CLEC-2L Activators
The chemical class of CLEC-2L activators encompasses a broad range of compounds that can indirectly influence the activation of the CLEC-2 receptor. These compounds do not interact directly with the CLEC-2 receptor but affect its activation through various pathways related to platelet function and thrombosis. Platelet activators like ADP, thrombin, and collagen can initiate a cascade of signaling events that culminate in the activation of CLEC-2. These activators work by either directly inducing conformational changes in platelet surface receptors or by stimulating the production of secondary messengers such as thromboxane A2 from arachidonic acid, which in turn amplify the activation signals for receptors including CLEC-2.
On the other hand, non-physiological activators like ionophores (Ionomycin and A23187) increase intracellular calcium levels, a crucial second messenger in platelet activation pathways, which is necessary for the full activation of CLEC-2 signaling during platelet aggregation and thrombus formation. Similarly, the protein kinase C activator PMA, and the thrombin receptor-activating peptide SFLLRN, act on signaling pathways that can lead to the enhancement of CLEC-2-mediated effects on platelets.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP stimulates platelets and can amplify the signaling through CLEC-2 upon its binding to podoplanin. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin is a potent platelet activator that can enhance CLEC-2-mediated platelet aggregation. | ||||||
Collagen IV | sc-29010 | 1 mg | $224.00 | 11 | ||
Collagen is involved in platelet activation and could synergize with CLEC-2 signaling pathways. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Metabolized to thromboxane A2 in platelets, it can potentiate CLEC-2 signaling. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Can enhance platelet aggregation and potentially increase CLEC-2-mediated effects. | ||||||
3-(2-Aminoethyl)-1H-indol-5-ol | 50-67-9 | sc-298707 | 1 g | $530.00 | 3 | |
Acts as a platelet activator and could augment CLEC-2 function in thrombosis. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Calcium ionophore that increases intracellular Ca2+, possibly enhancing CLEC-2-mediated responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Activator of protein kinase C, which could enhance downstream CLEC-2 signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A calcium ionophore that might enhance the activation of CLEC-2 by increasing intracellular calcium. | ||||||