CLC-4 Inhibitors
CLC-4 inhibitors represent a class of chemical compounds designed to specifically target and modulate the activity of CLC-4 chloride channels within biological systems. These chloride channels belong to the CLC family of proteins, which are responsible for facilitating the transport of chloride ions across cellular membranes. CLC-4, in particular, plays a crucial role in regulating chloride ion flux in various tissues and organs, including the kidney, brain, and lung. These channels are involved in maintaining cellular ion homeostasis, which is essential for normal physiological processes. CLC-4 inhibitors are designed to selectively block or reduce the activity of these channels, thereby influencing the flow of chloride ions across cell membranes. This modulation of ion transport can have significant downstream effects on cellular functions and signaling pathways.
The development of CLC-4 inhibitors has garnered attention due to their potential implications in various physiological and pathological processes. By inhibiting CLC-4 channels, these compounds may impact the regulation of cell volume, neuronal excitability, and ion transport across epithelial tissues. Consequently, the modulation of CLC-4 activity may hold promise in addressing conditions associated with disrupted chloride ion homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
This is a nonsteroidal anti-inflammatory drug that can block chloride channels, potentially altering the function of CLCN3. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $57.00 $77.00 | 2 | |
Known to modulate chloride channels, could alter CLCN3 activity by changing chloride ion flow. | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $41.00 | ||
A loop diuretic that can inhibit chloride channels in the thick ascending limb of the loop of Henle and may affect CLCN3 indirectly. | ||||||
Clofibric acid | 882-09-7 | sc-203000 sc-203000A | 10 g 50 g | $24.00 $40.00 | 1 | |
A derivative of fibric acid that has been shown to block chloride channels and could influence CLCN3 indirectly. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
This is a member of the fenamate group of nonsteroidal anti-inflammatory drugs and known to block chloride channels which could affect CLCN3. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
A polyphenol that may interact with chloride channels and could modulate CLCN3 function by this mechanism. | ||||||
Mefloquine Hydrochloride | 51773-92-3 | sc-211784 | 100 mg | $118.00 | 4 | |
Mefloquine Hydrochloride blocks chloride channels and could consequently affect the activity of CLCN3. | ||||||
Tamoxifen | 10540-29-1 | sc-208414 | 2.5 g | $272.00 | 18 | |
Although primarily known for other actions, it has been shown to affect chloride channel activity and could thereby influence CLCN3. | ||||||