Clathrin LCA Activators
Clathrin LCA activators encompass a diverse group of chemicals that exert their influence indirectly on the functionality of Clathrin LCA. These activators are primarily involved in modulating cellular signaling pathways, membrane dynamics, and cytoskeletal structures, all of which are crucial for the proper functioning of Clathrin LCA in vesicle formation and trafficking. Compounds like NAD+, GTPγS, and PIP2 play significant roles in energy metabolism and membrane dynamics, which are fundamental for the recruitment and function of Clathrin LCA in cellular processes.
For instance, alterations in membrane composition or cytoskeletal arrangements by agents such as Methyl-β-cyclodextrin, Jasplakinolide, and Cytochalasin D can significantly influence Clathrin LCA's role in the formation and trafficking of clathrin-coated vesicles. Furthermore, the regulatory role of these activators in signaling pathways like those modulated by Wortmannin (PI3K inhibitor) and Brefeldin A (Golgi apparatus disruptor) showcases the complexity of Clathrin LCA's activation mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
A coenzyme in redox reactions, crucial for energy metabolism. Its abundance can influence cellular processes including vesicle formation, potentially affecting Clathrin LCA function. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
An ionophore that alters intracellular ion concentrations, potentially affecting cellular trafficking pathways and indirectly influencing Clathrin LCA activity. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $25.00 $65.00 $170.00 $110.00 | 19 | |
Extracts cholesterol from membranes, altering membrane fluidity and potentially affecting Clathrin LCA-mediated endocytosis. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments, potentially influencing the cytoskeletal dynamics involved in Clathrin LCA-mediated vesicle trafficking. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Disrupts actin polymerization, which can influence vesicle formation and trafficking processes involving Clathrin LCA. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
A PI3K inhibitor, affecting the phosphoinositide signaling pathway, which can indirectly modulate Clathrin LCA's involvement in vesicular transport. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases 1 and 2A, affecting numerous cellular processes, including those potentially influencing Clathrin LCA activity. | ||||||