Date published: 2026-4-1

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Clathrin LCA Inhibitors

The chemical class referred to as Clathrin LCA Inhibitors encompasses a group of small molecules and compounds that have demonstrated the ability to interfere with the clathrin-mediated endocytosis process. Clathrin-mediated endocytosis is a fundamental cellular mechanism involved in the internalization of various molecules, including proteins and nutrients, through the formation of clathrin-coated vesicles. These inhibitors are designed to modulate or disrupt the assembly and function of the clathrin lattice, thereby affecting the formation of these vesicles. By targeting specific components or steps within the clathrin-mediated endocytosis pathway, Clathrin LCA Inhibitors offer a means to manipulate cellular processes for research purposes.

Their use provides valuable insights into the intricate mechanisms governing endocytosis, unveiling avenues for further investigation into cell biology and molecular interactions. While these inhibitors hold significant promise in elucidating the underlying processes of clathrin-mediated endocytosis, their detailed mechanisms of action and broader implications within cellular contexts continue to be subjects of ongoing scientific inquiry.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Pitstop 2

1419320-73-2sc-507418
10 mg
$360.00
(0)

A small molecule inhibitor that interferes with clathrin lattice assembly, leading to the inhibition of clathrin-coated vesicle formation.

Dynamin Inhibitor I, Dynasore

304448-55-3sc-202592
10 mg
$89.00
44
(2)

A non-competitive inhibitor of dynamin, a protein involved in the pinching off of clathrin-coated vesicles from the plasma membrane.

Chlorpromazine

50-53-3sc-357313
sc-357313A
5 g
25 g
$61.00
$110.00
21
(1)

Originally an antipsychotic drug, it has been found to inhibit clathrin-mediated endocytosis by affecting clathrin lattice dynamics.

Dansylcadaverine

10121-91-2sc-214851
sc-214851A
sc-214851B
100 mg
250 mg
1 g
$52.00
$89.00
$240.00
4
(1)

A polyamine compound that disrupts clathrin-coated pit formation and inhibits endocytosis.

Methyl-β-cyclodextrin

128446-36-6sc-215379A
sc-215379
sc-215379C
sc-215379B
100 mg
1 g
10 g
5 g
$20.00
$48.00
$160.00
$82.00
19
(1)

A compound that depletes cholesterol from the plasma membrane, affecting the organization of clathrin-coated pits.

Concanavalin A

11028-71-0sc-203007
sc-203007A
sc-203007B
50 mg
250 mg
1 g
$119.00
$364.00
$947.00
17
(2)

A lectin that can specifically inhibit clathrin-mediated endocytosis by interfering with clathrin lattice assembly.

Filipin III

480-49-9sc-205323
sc-205323A
500 µg
1 mg
$118.00
$148.00
26
(2)

A polyene antifungal antibiotic that disrupts lipid rafts and inhibits clathrin-mediated endocytosis.

Progesterone

57-83-0sc-296138A
sc-296138
sc-296138B
1 g
5 g
50 g
$20.00
$52.00
$298.00
3
(1)

This hormone has been reported to inhibit clathrin-mediated endocytosis, likely by modulating cellular lipid composition.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Although mainly known for its effect on the Golgi apparatus, it can also disrupt clathrin-mediated endocytosis by interfering with vesicle trafficking.