The chemical class referred to as Clathrin LCA Inhibitors encompasses a group of small molecules and compounds that have demonstrated the ability to interfere with the clathrin-mediated endocytosis process. Clathrin-mediated endocytosis is a fundamental cellular mechanism involved in the internalization of various molecules, including proteins and nutrients, through the formation of clathrin-coated vesicles. These inhibitors are designed to modulate or disrupt the assembly and function of the clathrin lattice, thereby affecting the formation of these vesicles. By targeting specific components or steps within the clathrin-mediated endocytosis pathway, Clathrin LCA Inhibitors offer a means to manipulate cellular processes for research purposes.
Their use provides valuable insights into the intricate mechanisms governing endocytosis, unveiling avenues for further investigation into cell biology and molecular interactions. While these inhibitors hold significant promise in elucidating the underlying processes of clathrin-mediated endocytosis, their detailed mechanisms of action and broader implications within cellular contexts continue to be subjects of ongoing scientific inquiry.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
A small molecule inhibitor that interferes with clathrin lattice assembly, leading to the inhibition of clathrin-coated vesicle formation. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
A non-competitive inhibitor of dynamin, a protein involved in the pinching off of clathrin-coated vesicles from the plasma membrane. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Originally an antipsychotic drug, it has been found to inhibit clathrin-mediated endocytosis by affecting clathrin lattice dynamics. | ||||||
Dansylcadaverine | 10121-91-2 | sc-214851 sc-214851A sc-214851B | 100 mg 250 mg 1 g | $52.00 $89.00 $240.00 | 4 | |
A polyamine compound that disrupts clathrin-coated pit formation and inhibits endocytosis. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
A compound that depletes cholesterol from the plasma membrane, affecting the organization of clathrin-coated pits. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
A lectin that can specifically inhibit clathrin-mediated endocytosis by interfering with clathrin lattice assembly. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
A polyene antifungal antibiotic that disrupts lipid rafts and inhibits clathrin-mediated endocytosis. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
This hormone has been reported to inhibit clathrin-mediated endocytosis, likely by modulating cellular lipid composition. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Although mainly known for its effect on the Golgi apparatus, it can also disrupt clathrin-mediated endocytosis by interfering with vesicle trafficking. | ||||||