CKAP2L Activators
CKAP2L activators primarily center around modulating microtubule dynamics and stability within cells, especially during processes like mitosis. Taxol, a renowned microtubule stabilizer, binds directly to the beta-tubulin subunit, thus preventing microtubules from undergoing depolymerization. This stabilization of the microtubules can indirectly buttress the activity and role of CKAP2L, reinforcing its significance in cellular division. Similarly, agents like Vinblastine and Colchicine that respectively disrupt or inhibit microtubule assembly represent another facet of the CKAP2L activators. Their modes of action, by stressing the microtubule network, can possibly elicit a compensatory rise in CKAP2L activity, as the cell attempts to regain homeostasis.
Furthermore, the intricacies of spindle dynamics present another route for CKAP2L modulation. Compounds like S-Trityl-L-cysteine and Monastrol, which inhibit mitotic kinesins, lead to perturbations in the mitotic spindle, and as a corollary, can induce changes in CKAP2L activity. Given that CKAP2L has an integral role in spindle formation, any disturbance to this structure often beckons a response from associated proteins.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Binds to the beta-tubulin subunit of microtubules, stabilizing them and preventing depolymerization. By stabilizing microtubules, it indirectly promotes the function of proteins like CKAP2L. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Disrupts microtubule assembly. Stressed microtubule dynamics can elevate CKAP2L activity in compensation. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds to tubulin, inhibiting microtubule polymerization. This can indirectly upregulate proteins involved in microtubule stabilization, like CKAP2L. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubule dynamics by inhibiting polymerization. Disturbances in dynamics can elevate CKAP2L activity for cellular compensation. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Promotes tubulin polymerization, indirectly promoting CKAP2L's role in microtubule stabilization. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
Inhibits mitotic kinesin Eg5 leading to mitotic arrest. This can indirectly modulate CKAP2L function in response to altered spindle dynamics. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Inhibits kinesin Eg5, affecting spindle formation. Can indirectly modulate CKAP2L activity. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Disrupts mitotic spindle through interacting with polymerized microtubules, which can indirectly influence CKAP2L activity. | ||||||
Estramustine | 2998-57-4 | sc-353281 sc-353281A | 100 mg 1 g | $265.00 $743.00 | ||
Binds to microtubule-associated proteins affecting microtubule dynamics, which can indirectly affect CKAP2L. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
Interferes with microtubule formation, indirectly modulating CKAP2L activity in response to disrupted microtubule dynamics. | ||||||