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CHP1 Inhibitors

Chemical inhibitors of CHP1 can affect its function through various mechanisms, primarily targeting the protein stabilization and degradation pathways. Geldanamycin and its derivative 17-AAG (Tanespimycin) both function by binding to heat shock protein 90 (Hsp90), a molecular chaperone that is critical for the proper folding and stability of many client proteins. By inhibiting Hsp90, these chemicals disrupt the maturation process of CHP1, leading to its instability and degradation. Similarly, PU-H71 and Onalespib are Hsp90 inhibitors that impair the chaperone cycle of Hsp90, resulting in the functional inhibition of CHP1 by promoting its degradation. Radicicol also targets Hsp90 by binding to its ATP-binding domain, preventing the interaction with CHP1, which leads to the destabilization and subsequent degradation of CHP1. The proteasome inhibitors MG-132, Withaferin A, Epoxomicin, Lactacystin, and Bortezomib disrupt the proteostasis network within the cell. By inhibiting the proteasome, these chemicals prevent the degradation of polyubiquitinated proteins, among them potentially misfolded or damaged CHP1. The accumulation of these proteins can lead to a toxic cellular environment where the misfolded CHP1 aggregates, resulting in its functional inhibition. Celastrol, while also influencing the heat shock response, can inhibit proteasome activity, which may lead to an increase in misfolded CHP1 and its aggregation, thereby inhibiting its function. Additionally, Zerumbone suppresses the activity of NF-kB, a transcription factor that regulates the expression of various proteins. By inhibiting NF-kB, Zerumbone may not directly affect the stability of CHP1 but can decrease its levels inside the cell by reducing its transcription. This reduction in protein levels can be sufficient to functionally inhibit CHP1, as the protein can no longer carry out its cellular role effectively due to its diminished presence.

Items 1 to 10 of 11 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Geldanamycin	30562-34-6	sc-200617B sc-200617C sc-200617 sc-200617A	100 µg 500 µg 1 mg 5 mg	$38.00 $58.00 $102.00 $202.00	8	(1)
Geldanamycin binds to heat shock protein 90 (Hsp90) and inhibits its chaperone function, which is essential for the stabilization and proper function of its client proteins, including CHP1. Inhibition of Hsp90 can lead to the degradation of CHP1.
17-AAG	75747-14-7	sc-200641 sc-200641A	1 mg 5 mg	$66.00 $153.00	16	(2)
17-AAG is an ansamycin antibiotic that inhibits Hsp90, a chaperone responsible for the maturation of many signaling proteins. CHP1, being dependent on Hsp90 for its stability, can be destabilized and functionally inhibited by 17-AAG.
Radicicol	12772-57-5	sc-200620 sc-200620A	1 mg 5 mg	$90.00 $326.00	13	(1)
Radicicol binds to the ATP-binding domain of Hsp90, preventing its interaction with client proteins like CHP1. This disruption leads to the functional inhibition of CHP1 by destabilizing it.
AT13387	912999-49-6	sc-364415 sc-364415A	10 mg 50 mg	$555.00 $1606.00		(0)
Onalespib is an Hsp90 inhibitor that disrupts its chaperoning activity, crucial for the stability and activity of many client proteins, including CHP1. Onalespib binding leads to the degradation of CHP1, inhibiting its function.
Zerumbone	471-05-6	sc-364148 sc-364148A	10 mg 50 mg	$110.00 $400.00		(0)
Zerumbone is an inhibitor of NF-kB, a transcription factor that regulates the expression of various proteins. Inhibition of NF-kB can reduce the cellular levels of CHP1 by preventing its transcription.
Celastrol, Celastrus scandens	34157-83-0	sc-202534	10 mg	$155.00	6	(1)
Celastrol is a quinone methide triterpene that inhibits the proteasome and can also induce heat shock response. Proteasome inhibition can lead to reduced degradation of misfolded CHP1, causing its functional inhibition through aggregation.
MG-132 [Z-Leu- Leu-Leu-CHO]	133407-82-6	sc-201270 sc-201270A sc-201270B	5 mg 25 mg 100 mg	$56.00 $260.00 $980.00	163	(3)
MG-132 is a proteasome inhibitor that can cause the accumulation of polyubiquitinated proteins. This accumulation may lead to the aggregated dysfunction of client proteins like CHP1, impairing its normal function.
Withaferin A	5119-48-2	sc-200381 sc-200381A sc-200381B sc-200381C	1 mg 10 mg 100 mg 1 g	$127.00 $572.00 $4090.00 $20104.00	20	(1)
Withaferin A is an inhibitor of the proteasomal pathway, which plays a crucial role in the degradation of proteins. Inhibition of this pathway can lead to the accumulation and possible misfolding of CHP1, leading to its functional inhibition.
Epoxomicin	134381-21-8	sc-201298C sc-201298 sc-201298A sc-201298B	50 µg 100 µg 250 µg 500 µg	$134.00 $215.00 $440.00 $496.00	19	(2)
Epoxomicin is a selective proteasome inhibitor. By preventing the degradation of misfolded or damaged proteins, it can indirectly lead to the functional inhibition of CHP1 through the disruption of cellular proteostasis.
Lactacystin	133343-34-7	sc-3575 sc-3575A	200 µg 1 mg	$165.00 $575.00	60	(2)
Lactacystin is a specific inhibitor of the proteasome that can lead to the accumulation of ubiquitinated proteins. This accumulation can disrupt the normal function of CHP1 by causing a proteotoxic stress that affects its folding and stability.

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CHP1 Inhibitors

Geldanamycin

17-AAG

Radicicol

AT13387

Zerumbone

Celastrol, Celastrus scandens

MG-132 [Z-Leu- Leu-Leu-CHO]

Withaferin A

Epoxomicin

Lactacystin