The class of CHMP5 activators encompasses a range of chemicals that, while not directly interacting with CHMP5, play a significant role in modulating the cellular pathways and processes that are essential for CHMP5's function in the ESCRT machinery. The primary focus of these activators is on influencing endosomal sorting, MVB formation, and the trafficking of ubiquitinated proteins, which are key areas where CHMP5 is known to be involved. This compound is a metabolite of Vitamin A and is known for its role in gene transcription regulation. In the context of CHMP5, all-trans retinoic acid can enhance endosomal sorting and MVB formation. It modulates gene expression related to endocytic pathways, potentially increasing the efficiency of CHMP5 in sorting ubiquitinated proteins into MVBs. There are alterations in endosomal pH, disruptions in endocytic pathways, and effects on microtubule dynamics can indirectly modulate CHMP5's activity.
There can be a shift to a more detailed analysis of specific chemicals and their modes of action. For instance, the effects of all-trans retinoic acid in stimulating endosomal sorting, the role of EGF in inducing endocytosis, and the impact of bafilomycin A1 on vacuolar H+-ATPase would be examined. This section would also cover how disruptions caused by agents like monensin, wortmannin, and nocodazole translate into alterations in CHMP5's function. The objective would be to provide a comprehensive overview of how these various chemicals, through their unique mechanisms, contribute to the regulation of CHMP5 activity within the cell, thereby offering insights into the indirect modulation of this protein's function.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Stimulates endosomal sorting and MVB formation, potentially enhancing CHMP5 function. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Inhibits vacuolar H+-ATPase, affecting endosome acidification and potentially CHMP5's role in MVB formation. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Disrupts endosomal pH gradient, indirectly affecting CHMP5-mediated MVB sorting. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
Alters cholesterol trafficking and endosomal sorting, potentially impacting CHMP5 function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Disrupts microtubule dynamics, indirectly affecting endosomal transport and CHMP5. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Inhibits dynamin, affecting endocytosis and potentially CHMP5's role in MVB formation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Alters endosomal pH, potentially influencing CHMP5-mediated processes. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Inhibits tyrosine kinases, affecting endocytic pathways and potentially CHMP5 activity. | ||||||
FCM Lysing solution (1x) | sc-3621 | 150 ml | $61.00 | 8 | ||
Raises endosomal pH, potentially affecting CHMP5's function in MVB formation. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Disrupts actin polymerization, affecting endocytosis and indirectly CHMP5 activity. |