Date published: 2025-10-20

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CHMP5 Activators

The class of CHMP5 activators encompasses a range of chemicals that, while not directly interacting with CHMP5, play a significant role in modulating the cellular pathways and processes that are essential for CHMP5's function in the ESCRT machinery. The primary focus of these activators is on influencing endosomal sorting, MVB formation, and the trafficking of ubiquitinated proteins, which are key areas where CHMP5 is known to be involved. This compound is a metabolite of Vitamin A and is known for its role in gene transcription regulation. In the context of CHMP5, all-trans retinoic acid can enhance endosomal sorting and MVB formation. It modulates gene expression related to endocytic pathways, potentially increasing the efficiency of CHMP5 in sorting ubiquitinated proteins into MVBs. There are alterations in endosomal pH, disruptions in endocytic pathways, and effects on microtubule dynamics can indirectly modulate CHMP5's activity.

There can be a shift to a more detailed analysis of specific chemicals and their modes of action. For instance, the effects of all-trans retinoic acid in stimulating endosomal sorting, the role of EGF in inducing endocytosis, and the impact of bafilomycin A1 on vacuolar H+-ATPase would be examined. This section would also cover how disruptions caused by agents like monensin, wortmannin, and nocodazole translate into alterations in CHMP5's function. The objective would be to provide a comprehensive overview of how these various chemicals, through their unique mechanisms, contribute to the regulation of CHMP5 activity within the cell, thereby offering insights into the indirect modulation of this protein's function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Stimulates endosomal sorting and MVB formation, potentially enhancing CHMP5 function.

Bafilomycin A1

88899-55-2sc-201550
sc-201550A
sc-201550B
sc-201550C
100 µg
1 mg
5 mg
10 mg
$96.00
$250.00
$750.00
$1428.00
280
(6)

Inhibits vacuolar H+-ATPase, affecting endosome acidification and potentially CHMP5's role in MVB formation.

Monensin A

17090-79-8sc-362032
sc-362032A
5 mg
25 mg
$152.00
$515.00
(1)

Disrupts endosomal pH gradient, indirectly affecting CHMP5-mediated MVB sorting.

U 18666A

3039-71-2sc-203306
sc-203306A
10 mg
50 mg
$140.00
$500.00
2
(1)

Alters cholesterol trafficking and endosomal sorting, potentially impacting CHMP5 function.

Nocodazole

31430-18-9sc-3518B
sc-3518
sc-3518C
sc-3518A
5 mg
10 mg
25 mg
50 mg
$58.00
$83.00
$140.00
$242.00
38
(2)

Disrupts microtubule dynamics, indirectly affecting endosomal transport and CHMP5.

Dynamin Inhibitor I, Dynasore

304448-55-3sc-202592
10 mg
$87.00
44
(2)

Inhibits dynamin, affecting endocytosis and potentially CHMP5's role in MVB formation.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Alters endosomal pH, potentially influencing CHMP5-mediated processes.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

Inhibits tyrosine kinases, affecting endocytic pathways and potentially CHMP5 activity.

FCM Lysing solution (1x)

sc-3621
150 ml
$61.00
8
(1)

Raises endosomal pH, potentially affecting CHMP5's function in MVB formation.

Cytochalasin D

22144-77-0sc-201442
sc-201442A
1 mg
5 mg
$145.00
$442.00
64
(4)

Disrupts actin polymerization, affecting endocytosis and indirectly CHMP5 activity.