CHD (chromodomain helicase) Inhibitors
The CHD (chromodomain helicase DNA-binding) family of proteins are ATP-dependent chromatin remodelers that play a crucial role in the regulation of gene expression. These proteins possess a chromodomain, enabling them to specifically recognize and bind to methylated histone tails, a key feature in the epigenetic control of gene expression. This remodeling activity is essential for various cellular processes, including transcriptional regulation, DNA repair, and chromosome organization. CHD proteins can act as both activators and repressors of transcription, depending on the context and specific interactions with other regulatory molecules. Their function and signaling pathways are tightly regulated, and dysregulation of CHD proteins is associated with developmental disorders, neurological disorders, and cancers.
Targeting CHD (chromodomain helicase DNA-binding) proteins with small molecules for disruption or inhibition provides a valuable tool for understanding their mechanistic roles in cellular processes. For instance, inhibiting the ATPase activity of CHD proteins can reveal their role in chromatin remodeling and its impact on transcriptional regulation. Additionally, using small molecule inhibitors to block the interaction between CHD proteins and methylated histones can help in determining how these proteins recognize and bind to specific chromatin marks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is an inhibitor of histone deacetylase which can affect the acetylation status of histones, thereby influencing chromatin structure and CHD (chromodomain helicase DNA-binding) function. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Mocetinostat is a histone deacetylase inhibitor that can modify the acetylation status of histones and influence the chromatin structure and CHD (chromodomain helicase DNA-binding) activity. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 is a BET bromodomain inhibitor that can modulate the recognition of acetylated histones, potentially affecting the chromatin remodeling activities of CHD (chromodomain helicase DNA-binding). | ||||||
GSK 525762A | 1260907-17-2 | sc-490339 sc-490339A sc-490339B sc-490339C sc-490339D | 5 mg 10 mg 50 mg 100 mg 1 g | $300.00 $540.00 $940.00 $1680.00 $5900.00 | ||
I-BET762 is a BET bromodomain inhibitor that can modulate the recognition of acetylated histones, thereby affecting the chromatin remodeling activities of CHD (chromodomain helicase DNA-binding). | ||||||
GSK126 | 1346574-57-9 | sc-490133 sc-490133A sc-490133B | 1 mg 5 mg 10 mg | $92.00 $243.00 $306.00 | ||
GSK126 is another EZH2 inhibitor that can affect histone methylation status, thereby influencing the chromatin remodeling activities of CHD (chromodomain helicase DNA-binding). | ||||||
UNC1999 | 1431612-23-5 | sc-475314 | 5 mg | $142.00 | 1 | |
UNC1999 is an inhibitor of EZH2 and EZH1 that can affect histone methylation status and influence the activity of CHD (chromodomain helicase DNA-binding). | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $135.00 | 5 | |
DZNep is an inhibitor of EZH2 that can affect histone methylation status and influence the activity of CHD (chromodomain helicase DNA-binding). | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 is an inhibitor of G9a and GLP histone methyltransferases that can affect histone methylation, thereby influencing the chromatin remodeling activities of CHD (chromodomain helicase DNA-binding). | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor influencing CHD (chromodomain helicase DNA-binding) by preventing protein degradation, leading to increased CHD (chromodomain helicase DNA-binding) levels and altered cellular functions. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Inhibitor of MDM2, indirectly affecting CHD (chromodomain helicase DNA-binding) by stabilizing p53 and influencing downstream pathways related to CHD (chromodomain helicase DNA-binding) activity. | ||||||