CHCHD3 Activators
CHCHD3 activators encompass a diverse group of compounds that indirectly enhance the functional activity of CHCHD3 through various mitochondrial pathways. For instance, polyphenolic compounds such as Resveratrol activate SIRT1, which influences mitochondrial biogenesis by deacetylating PGC-1α, a coactivator that directly impacts mitochondrial quantity and quality. This process would likely bolster the activity of CHCHD3 by ensuring an optimal mitochondrial environment. Similarly, direct PGC-1αactivators like CAY10566 or AMPK activators such as AICAR and Metformin also work indirectly by upregulating mitochondrial biogenesis, which is expected to promote CHCHD3 function due to the protein's localization in the mitochondrial inner membrane. Other compounds, like NAD+ and SRT1720, enhance sirtuin activity, which further supports mitochondrial health, indirectly contributing to the functional enhancement of CHCHD3. Furthermore, agents SS-31 (Elamipretide) modulate mitochondrial dynamics, stabilizing mitochondrial membranes to maintain mitochondrial integrity.
Additionally, compounds like Bezafibrate and Leucine act as indirect activators by stimulating peroxisome proliferator-activated receptors and mTOR signaling, respectively, both leading to increased mitochondrial biogenesis and potentially improving CHCHD3 function. Urolithin A's promotion of mitophagy ensures the removal of dysfunctional mitochondria, leading to a healthier mitochondrial population that could indirectly enhance CHCHD3's role in mitochondrial structure and function. Coenzyme Q10's role in ATP synthesis is crucial for maintaining the mitochondrial energy balance, and its optimization of energy production is another route through which CHCHD3 activity could be indirectly enhanced, as CHCHD3 is vital for maintaining mitochondrial network organization and integrity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound known to activate SIRT1, which in turn influences mitochondrial biogenesis through PGC-1α deacetylation. CHCHD3, being a mitochondrial inner membrane protein, may have its functional activity enhanced due to increased mitochondrial biogenesis and improved mitochondrial function. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
Nicotinamide adenine dinucleotide (NAD+) is essential for metabolism and mitochondrial health. It is a substrate for sirtuins, which regulate mitochondrial biogenesis through PGC-1α. Enhanced levels of NAD+ could boost sirtuin activity thereby indirectly enhancing CHCHD3 activity by promoting a favorable mitochondrial environment. | ||||||
CAY 10566 | 944808-88-2 | sc-205109 sc-205109A sc-205109B | 1 mg 5 mg 25 mg | $117.00 $512.00 $1527.00 | 4 | |
This synthetic compound is a direct activator of PGC-1α, a master regulator of mitochondrial biogenesis. By activating PGC-1α, this compound likely increases mitochondrial content and function, which would indirectly boost CHCHD3 activity as it is integral to mitochondrial structure. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate is a PPAR agonist that has been shown to induce mitochondrial biogenesis through PGC-1α activation. This increased mitochondrial biogenesis may enhance the function of mitochondrial proteins like CHCHD3 by improving overall mitochondrial health and function. | ||||||
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
Leucine is an amino acid that has been found to stimulate mTOR signaling, which can lead to increased protein synthesis and mitochondrial biogenesis. The enhanced mitochondrial biogenesis may indirectly increase the activity of CHCHD3 through more robust mitochondrial function. | ||||||
Urolithin A | 1143-70-0 | sc-475514 sc-475514A sc-475514B sc-475514C | 25 mg 100 mg 1 g 5 g | $204.00 $459.00 $714.00 $1224.00 | 10 | |
Urolithin A is a metabolite found in ellagitannins that induces mitophagy, the selective degradation of mitochondria by autophagy. By promoting the turnover of mitochondria, Urolithin A may lead to a population of healthier mitochondria, potentially enhancing the activity of CHCHD3. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator that can stimulate mitochondrial biogenesis through PGC-1α. Increased AMPK activity leads to enhanced mitochondrial function and could indirectly increase CHCHD3 activity by promoting mitochondrial health. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
SRT1720 is a SIRT1 activator, which can lead to deacetylation of PGC-1α, thereby enhancing mitochondrial biogenesis. As CHCHD3 is a mitochondrial protein, its activity could be enhanced by improved mitochondrial function and increased biogenesis. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin is an AMPK activator commonly used as an antidiabetic drug. By activating AMPK, it promotes mitochondrial biogenesis and function, which may indirectly enhance the activity of CHCHD3, due to the improved health of the mitochondrial network. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is involved in the electron transport chain and is essential for mitochondrial ATP synthesis. By supporting mitochondrial energy production, it could indirectly enhance the function of CHCHD3, a mitochondrial inner membrane protein. | ||||||