Date published: 2025-10-15

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CHCHD3 Inhibitors

CHCHD3 inhibitors primarily include compounds targeting mitochondrial function and cellular metabolism. Rapamycin, Oligomycin A, FCCP, Rotenone, Antimycin A, CCCP, A769662, UK5099, Metformin, ETC-1002 (Bempedoic Acid), Mdivi-1, and Atractyloside represent a diverse set of molecules that can indirectly modulate CHCHD3 through their impact on specific cellular pathways. Mitochondrial dynamics and energetics are crucial for cellular homeostasis, and CHCHD3 plays a role in mitochondrial function. Rapamycin, an mTOR inhibitor, indirectly influences CHCHD3 by modulating the PI3K/Akt/mTOR pathway. Oligomycin A disrupts oxidative phosphorylation, impacting CHCHD3 indirectly by altering ATP production. FCCP and CCCP, uncoupling agents, disturb mitochondrial membrane potential, affecting CHCHD3-dependent processes. Rotenone and Antimycin A, inhibitors of mitochondrial electron transport, induce alterations in mitochondrial function, potentially impacting CHCHD3. Compounds like A769662, and UK5099, modulators of AMP-activated protein kinase (AMPK), indirectly influence CHCHD3 through energy sensing and metabolism. ETC-1002 (Bempedoic Acid), an ATP-citrate lyase inhibitor, and Mdivi-1, a Dynamin-related protein 1 (Drp1) inhibitor, target cellular lipid metabolism and mitochondrial fission, respectively, indirectly influencing CHCHD3. Atractyloside, an ADP/ATP translocase inhibitor, disrupts mitochondrial nucleotide exchange and impacts cellular energetics, potentially modulating CHCHD3-dependent processes. In summary, the diverse set of CHCHD3 inhibitors offers a range of mechanisms to modulate mitochondrial function and cellular metabolism, providing valuable tools for understanding the intricate interplay between CHCHD3 and cellular homeostasis.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

mTOR inhibitor affecting the PI3K/Akt/mTOR pathway. Rapamycin indirectly influences CHCHD3 by modulating mitochondrial function through mTORC1 inhibition. This alteration in mitochondrial dynamics can impact CHCHD3 indirectly, potentially affecting its cellular functions and interactions within the mitochondrial environment.

Oligomycin A

579-13-5sc-201551
sc-201551A
sc-201551B
sc-201551C
sc-201551D
5 mg
25 mg
100 mg
500 mg
1 g
$175.00
$600.00
$1179.00
$5100.00
$9180.00
26
(1)

ATP synthase inhibitor affecting oxidative phosphorylation. Oligomycin A indirectly influences CHCHD3 by disrupting ATP production and mitochondrial function. This metabolic stress can lead to alterations in CHCHD3-dependent processes, providing a potential avenue for modulating its cellular functions.

FCCP

370-86-5sc-203578
sc-203578A
10 mg
50 mg
$92.00
$348.00
46
(1)

Uncoupling agent impacting mitochondrial membrane potential. FCCP indirectly influences CHCHD3 by disrupting mitochondrial integrity and function. This disruption in mitochondrial homeostasis can modulate CHCHD3-dependent processes, offering a potential avenue for indirect inhibition of CHCHD3.

Rotenone

83-79-4sc-203242
sc-203242A
1 g
5 g
$89.00
$254.00
41
(1)

Complex I inhibitor impacting mitochondrial electron transport. Rotenone indirectly influences CHCHD3 by disrupting the electron transport chain, leading to alterations in mitochondrial function. These changes can impact CHCHD3-dependent processes, providing a potential avenue for modulating its cellular functions.

Antimycin A

1397-94-0sc-202467
sc-202467A
sc-202467B
sc-202467C
5 mg
10 mg
1 g
3 g
$54.00
$62.00
$1642.00
$4600.00
51
(1)

Complex III inhibitor affecting mitochondrial electron transport. Antimycin A indirectly influences CHCHD3 by disrupting the electron transport chain, leading to alterations in mitochondrial function. These changes can impact CHCHD3-dependent processes, providing a potential avenue for modulating its cellular functions.

Carbonyl Cyanide m-Chlorophenylhydrazone

555-60-2sc-202984A
sc-202984
sc-202984B
100 mg
250 mg
500 mg
$75.00
$150.00
$235.00
8
(1)

Uncoupling agent impacting mitochondrial membrane potential. CCCP indirectly influences CHCHD3 by disrupting mitochondrial integrity and function. This disruption in mitochondrial homeostasis can modulate CHCHD3-dependent processes, offering a potential avenue for indirect inhibition of CHCHD3.

A-769662

844499-71-4sc-203790
sc-203790A
sc-203790B
sc-203790C
sc-203790D
10 mg
50 mg
100 mg
500 mg
1 g
$180.00
$726.00
$1055.00
$3350.00
$5200.00
23
(2)

AMPK activator affecting cellular energy sensing. A769662 indirectly influences CHCHD3 by modulating AMPK activity and downstream pathways associated with energy metabolism. This metabolic modulation can impact CHCHD3-dependent processes, providing a potential avenue for indirect inhibition of CHCHD3.

UK 5099

56396-35-1sc-361394
sc-361394A
10 mg
50 mg
$154.00
$633.00
5
(1)

Inhibitor of mitochondrial pyruvate carrier. UK5099 indirectly influences CHCHD3 by disrupting mitochondrial pyruvate transport and altering cellular metabolism. These metabolic changes can impact CHCHD3-dependent processes, providing a potential avenue for modulating its cellular functions.

Mdivi-1

338967-87-6sc-215291
sc-215291B
sc-215291A
sc-215291C
5 mg
10 mg
25 mg
50 mg
$66.00
$124.00
$246.00
$456.00
13
(2)

Dynamin-related protein 1 (Drp1) inhibitor affecting mitochondrial fission. Mdivi-1 indirectly influences CHCHD3 by modulating mitochondrial dynamics and morphology. This alteration in mitochondrial structure can impact CHCHD3-dependent processes, providing a potential avenue for modulating its cellular functions.

Atractyloside A

126054-77-1sc-503160
5 mg
$380.00
(0)

ADP/ATP translocase inhibitor impacting mitochondrial energy metabolism. Atractyloside indirectly influences CHCHD3 by disrupting mitochondrial nucleotide exchange and altering cellular energetics. These metabolic changes can impact CHCHD3-dependent processes, providing a potential avenue for modulating its cellular functions.