CAY 10566 (CAS 944808-88-2)
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CAY 10566, also known as 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine, is utilized in molecular research to dissect the signaling pathways of neuroreceptors due to its structural affinity to known active compounds. Its application in biochemical assays facilitates the identification of molecular interactions that regulate neurotransmitter activity, providing researchers with clear insights into the modulation of synaptic transmission. The compound′s binding affinities are quantified to understand the structure-activity relationship, which guides the synthesis of more potent analogs. In enzyme kinetics, it serves as an inhibitor to study the regulation of key metabolic enzymes, offering a detailed view of metabolic control mechanisms. Moreover, this compound is instrumental in the synthesis of receptor-specific ligands, aiding in the exploration of receptor-mediated cellular processes.
CAY 10566 (CAS 944808-88-2) References
- Activating transcription factor 4 regulates stearate-induced vascular calcification. | Masuda, M., et al. 2012. J Lipid Res. 53: 1543-52. PMID: 22628618
- Palmitoleate is a mitogen, formed upon stimulation with growth factors, and converted to palmitoleoyl-phosphatidylinositol. | Koeberle, A., et al. 2012. J Biol Chem. 287: 27244-54. PMID: 22700983
- Fatty Acid Composition of Tissue Cultured Breast Carcinoma and the Effect of Stearoyl-CoA Desaturase 1 Inhibition. | Mohammadzadeh, F., et al. 2014. J Breast Cancer. 17: 136-42. PMID: 25013434
- Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis. | Koeberle, A., et al. 2015. FASEB J. 29: 2439-49. PMID: 25678624
- INHIBITION OF FATTY ACID DESATURASES IN Drosophila melanogaster LARVAE BLOCKS FEEDING AND DEVELOPMENTAL PROGRESSION. | Wang, Y., et al. 2016. Arch Insect Biochem Physiol. 92: 6-23. PMID: 27037621
- Primary Culture of Human Cumulus Cells Requires Stearoyl-Coenzyme A Desaturase 1 Activity for Steroidogenesis and Enhancing Oocyte In Vitro Maturation. | Fayezi, S., et al. 2018. Reprod Sci. 25: 844-853. PMID: 28345489
- Responses of MAC-T Cells to Inhibited Stearoyl-CoA Desaturase 1 during cis-9, trans-11 Conjugated Linoleic Acid Synthesis. | Wang, T., et al. 2018. Lipids. 53: 647-652. PMID: 30277580
- Stearoyl-coenzyme A desaturase 1 is required for lipid droplet formation in pig embryo. | Lee, DK., et al. 2019. Reproduction. 157: 235-243. PMID: 30576288
- Fatty acid synthase and stearoyl-CoA desaturase-1 are conserved druggable cofactors of Old World Alphavirus genome replication. | Bakhache, W., et al. 2019. Antiviral Res. 172: 104642. PMID: 31678479
- Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities. | Wang, Y., et al. 2020. Sci Rep. 10: 3490. PMID: 32103057
- Inhibition of stearoyl-coenzyme A desaturase 1 ameliorates hepatic steatosis by inducing AMPK-mediated lipophagy. | Zhou, Y., et al. 2020. Aging (Albany NY). 12: 7350-7362. PMID: 32324591
- Modulation of SCD1 activity in hepatocyte cell lines: evaluation of genomic stability and proliferation. | de Lima Luna, AC. and Forti, FL. 2021. Mol Cell Biochem. 476: 3393-3405. PMID: 33954906
- Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs. | Mizuno, M., et al. 2022. Stem Cell Res Ther. 13: 177. PMID: 35505370
- Proteomics Insights into the Gene Network of cis9, trans11-Conjugated Linoleic Acid Biosynthesis in Bovine Mammary Gland Epithelial Cells. | Peng, L., et al. 2022. Animals (Basel). 12: PMID: 35804617
- Isobaric 6-plex and tosyl dual tagging for the determination of positional isomers and quantitation of monounsaturated fatty acids using rapid UHPLC-MS/MS. | Armbruster, MR., et al. 2023. Analyst. 148: 297-304. PMID: 36533920
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CAY 10566, 1 mg | sc-205109 | 1 mg | $115.00 | |||
CAY 10566, 5 mg | sc-205109A | 5 mg | $502.00 | |||
CAY 10566, 25 mg | sc-205109B | 25 mg | $1497.00 |