cGKII Activators
SEE ALSO...
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt | 51239-26-0 | sc-202029 sc-202029A | 1 mg 5 mg | $46.00 $159.00 | ||
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate sodium salt acts as a potent modulator of intracellular signaling pathways, particularly influencing cyclic nucleotide dynamics. Its unique thioether linkage enhances binding affinity to specific phosphodiesterases, altering reaction kinetics and promoting sustained cGMP levels. This compound exhibits distinct molecular interactions that can lead to differential activation of protein kinases, thereby influencing various cellular processes and responses. | ||||||
Sp-8-pCPT-cyclic GMPS Sodium | 200716-65-0 | sc-202433 | 1 mg | $155.00 | ||
Sp-8-pCPT-cyclic GMPS Sodium is a specialized cyclic nucleotide that exhibits unique structural features, including a thioether moiety that enhances its stability and solubility in aqueous environments. This compound engages in selective interactions with target proteins, facilitating the modulation of enzymatic activities. Its distinct conformational flexibility allows for efficient binding to regulatory sites, influencing downstream signaling cascades and promoting specific cellular responses through altered phosphorylation patterns. | ||||||
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate triethylammonium salt | 54364-02-2 | sc-202432 sc-202432A | 1 mg 5 mg | $42.00 $168.00 | ||
8-(4-Chlorophenylthio)guanosine 3',5'-cyclic Monophosphate triethylammonium salt is a cyclic nucleotide characterized by its thioether linkage, which contributes to its unique reactivity and interaction profile. This compound demonstrates a propensity for forming stable complexes with various protein kinases, thereby influencing their activity. Its distinct electronic properties facilitate rapid conformational changes, enhancing its ability to modulate signaling pathways and affect cellular processes through targeted phosphorylation events. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $180.00 | 13 | |
Similar to Sildenafil, Tadalafil functions as a PDE5 inhibitor, increasing cGMP levels in cells, which in turn can lead to the activation of cGKII. | ||||||
Vardenafil | 224785-90-4 | sc-362054 sc-362054A sc-362054B | 100 mg 1 g 50 g | $526.00 $735.00 $16653.00 | 7 | |
Vardenafil is another PDE5 inhibitor that works by elevating cGMP concentrations, indirectly facilitating cGKII activation. | ||||||
Riociguat | 625115-55-1 | sc-476845 | 5 mg | $300.00 | ||
Riociguat, a soluble guanylate cyclase stimulator, enhances cGMP synthesis, indirectly promoting cGKII activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP, which can influence cGKII activity through cross-talk mechanisms between cAMP and cGMP pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $105.00 $250.00 | 8 | |
Zaprinast inhibits PDE5 and PDE6, leading to increased cGMP levels and potential activation of cGKII. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine, a PDE1 inhibitor, can indirectly affect cGKII activity by altering cGMP levels. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $109.00 $322.00 | 3 | |
Cilostazol inhibits PDE3 and increases cAMP levels, which can indirectly modulate cGKII activity through interplay between cAMP and cGMP pathways. | ||||||