Molecular structure of Sp-8-pCPT-cyclic GMPS Sodium, CAS Number: 160385-87-5
Sp-8-pCPT-cyclic GMPS Sodium (CAS 200716-65-0)
Application:
Sp-8-pCPT-cyclic GMPS Sodium is an activator of PKA, cGKI, and cGKII
CAS Number:
200716-65-0
Molecular Weight:
525.85
Molecular Formula:
C16H14N5ClO6S2P•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent activator of both cGMP-dependent protein kinase 1α, 1β and type II and cAMP-dependent protein kinase II. Excellent cell membrane permeability and phosphodiesterase stability.
Sp-8-pCPT-cyclic GMPS Sodium (CAS 200716-65-0) References
- SNV, a lipophilic superactive VIP analog, acts through cGMP to promote neuronal survival. | Ashur-Fabian, O., et al. 1999. Peptides. 20: 629-33. PMID: 10465516
- Effect of cGMP analogues and protein kinase G blocker on secretory activity, apoptosis and the cAMP/protein kinase A system in porcine ovarian granulosa cells in vitro. | Sirotkin, AV., et al. 2000. J Steroid Biochem Mol Biol. 74: 1-9. PMID: 11074350
- Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. | Spicuzza, L., et al. 2001. Br J Pharmacol. 133: 1201-12. PMID: 11498504
- cGMP-dependent and not cAMP-dependent kinase is required for adenosine-induced dilation of intracerebral arterioles. | West, GA., et al. 2003. J Cardiovasc Pharmacol. 41: 444-51. PMID: 12605023
- Interactions between cGMP- and cAMP-pathways are involved in the regulation of penile smooth muscle tone. | Uckert, S., et al. 2004. World J Urol. 22: 261-6. PMID: 15045518
- Regulation of intracellular Ca2+ and calcineurin by NO/PKG in proliferation of vascular smooth muscle cells. | Li, SJ. and Sun, NL. 2005. Acta Pharmacol Sin. 26: 323-8. PMID: 15715928
- Involvement of cyclic GMP-dependent protein kinase in nitrous oxide-induced anxiolytic-like behavior in the mouse light/dark exploration test. | Li, S., et al. 2005. Brain Res. 1038: 113-7. PMID: 15748880
- Phosphodiesterase 4 inhibitors and db-cAMP inhibit TNF-alpha release from human mononuclear cells. Effects of cAMP and cGMP-dependent protein kinase inhibitors. | Hichami, A., et al. 1996. Mediators Inflamm. 5: 425-8. PMID: 18475747
- The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. | Gamm, DM., et al. 1995. J Biol Chem. 270: 27380-8. PMID: 7593002
- (Rp)-8-pCPT-cGMPS, a novel cGMP-dependent protein kinase inhibitor. | Butt, E., et al. 1994. Eur J Pharmacol. 269: 265-8. PMID: 7851503
- Protein kinase G is not essential to NO-cGMP modulation of basal tone in rat pulmonary circulation. | Fouty, B., et al. 1998. Am J Physiol. 274: H672-8. PMID: 9486273
- Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel. | Wei, JY., et al. 1998. J Mol Neurosci. 10: 53-64. PMID: 9589370
- Regulation of sensory neuron precursor proliferation by cyclic GMP-dependent protein kinase. | Firestein, BL. and Bredt, DS. 1998. J Neurochem. 71: 1846-53. PMID: 9798908
Activator of:
cGKI α, cGKII, and PKA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sp-8-pCPT-cyclic GMPS Sodium, 1 mg | sc-202433 | 1 mg | $155.00 | |||
| US: (Out of Stock: Indefinite Backorder) | ||||||