Molecular structure of 8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate triethylammonium salt, CAS Number: 54364-02-2
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate triethylammonium salt (CAS 54364-02-2)
Alternate Names:
8-pCPT-cGMP•TEA
Application:
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate triethylammonium salt is an activator of protein kinase
CAS Number:
54364-02-2
Molecular Weight:
589.0
Molecular Formula:
C16H14ClN5O7PS•C6H16N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective activator of cGMP-dependent protein kinase Iα, Iβ and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate triethylammonium salt (CAS 54364-02-2) References
- Gene transfer of cGMP-dependent protein kinase I enhances the antihypertrophic effects of nitric oxide in cardiomyocytes. | Wollert, KC., et al. 2002. Hypertension. 39: 87-92. PMID: 11799084
- Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets. | Geiger, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 1031-5. PMID: 1310537
- Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP. | Butt, E., et al. 1992. Biochem Pharmacol. 43: 2591-600. PMID: 1321624
- Mechanism of cGMP-mediated protection in a cellular model of myocardial reperfusion injury. | Abdallah, Y., et al. 2005. Cardiovasc Res. 66: 123-31. PMID: 15769455
- Regulation of epithelial sodium channels by cGMP/PKGII. | Nie, HG., et al. 2009. J Physiol. 587: 2663-76. PMID: 19359370
- 8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties. | Nie, HG., et al. 2010. Am J Physiol Renal Physiol. 298: F323-34. PMID: 20007351
- Type II cGMP-dependent protein kinase inhibits proliferation of the gastric cancer cell line BGC-823. | Chen, YC., et al. 2010. Mol Med Rep. 3: 361-6. PMID: 21472248
- Epithelial sodium channel enhanced osteogenesis via cGMP/PKGII/ENaC signaling in rat osteoblast. | Chen, J., et al. 2014. Mol Biol Rep. 41: 2161-9. PMID: 24481877
- Influence of the cGMP analog 8-PCPT-cGMP on agonist-induced increases in cytosolic ionized Ca2+ and on aggregation of human platelets. | Menshikov MYu, ., et al. 1993. Eur J Pharmacol. 245: 281-4. PMID: 8392939
- cGMP facilitates calcium current via cGMP-dependent protein kinase in isolated rabbit ventricular myocytes. | Han, J., et al. 1998. Pflugers Arch. 435: 388-93. PMID: 9426295
- Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel. | Wei, JY., et al. 1998. J Mol Neurosci. 10: 53-64. PMID: 9589370
- Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells. | Gambaryan, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 9003-8. PMID: 9671794
- Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. | Smolenski, A., et al. 1998. Naunyn Schmiedebergs Arch Pharmacol. 358: 134-9. PMID: 9721015
Activator of:
cGKI α, and cGKII.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate triethylammonium salt, 1 mg | sc-202432 | 1 mg | $42.00 | |||
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate triethylammonium salt, 5 mg | sc-202432A | 5 mg | $168.00 |