Molecular structure of 8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt, CAS Number: 51239-26-0
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt (CAS 51239-26-0)
Alternate Names:
8-pCPT-cGMP•Na
Application:
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt is a selective activator of cGMP-dependent protein kinase
CAS Number:
51239-26-0
Purity:
≥99%
Molecular Weight:
509.8
Molecular Formula:
C16H14ClN5O7PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Selective activator of cGMP-dependent protein kinase (PKG) Iα, Iβ, and type II as well as of cGMP-gated ion channels. Higher activation potential as compared to cGMP; excellent cell membrane permeability and phosphodiesterase stability. Preferred alternative to unsuitable analogs such as dibutyryl-cGMP.
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt (CAS 51239-26-0) References
- Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets. | Geiger, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 1031-5. PMID: 1310537
- Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP. | Butt, E., et al. 1992. Biochem Pharmacol. 43: 2591-600. PMID: 1321624
- 8-pCPT-cGMP stimulates alphabetagamma-ENaC activity in oocytes as an external ligand requiring specific nucleotide moieties. | Nie, HG., et al. 2010. Am J Physiol Renal Physiol. 298: F323-34. PMID: 20007351
- Stainless steel ions stimulate increased thrombospondin-1-dependent TGF-beta activation by vascular smooth muscle cells: implications for in-stent restenosis. | Pallero, MA., et al. 2010. J Vasc Res. 47: 309-22. PMID: 20016205
- 8-(4-chlorophenylthio)-guanosine-3',5'-cyclic monophosphate-Na stimulates human alveolar fluid clearance by releasing external Na+ self-inhibition of epithelial Na+ channels. | Han, DY., et al. 2011. Am J Respir Cell Mol Biol. 45: 1007-14. PMID: 21562313
- The sGC activator inhibits the proliferation and migration, promotes the apoptosis of human pulmonary arterial smooth muscle cells via the up regulation of plasminogen activator inhibitor-2. | Zhang, S., et al. 2015. Exp Cell Res. 332: 278-87. PMID: 25704756
Activator of:
cGKI α, cGKII, CNG, and Ovalbumin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt, 1 mg | sc-202029 | 1 mg | $46.00 | |||
8-(4-Chlorophenylthio)guanosine 3′,5′-cyclic Monophosphate sodium salt, 5 mg | sc-202029A | 5 mg | $159.00 |