cGKI Activators

8-Bromo-cGMP is a potent cGMP analog that selectively activates cGMP-dependent protein kinase I (cGKI). Its unique bromine substitution enhances binding affinity, facilitating specific interactions with cGKI's regulatory domain. This compound influences downstream signaling pathways by modulating phosphorylation states, leading to distinct cellular responses. The presence of the bromine atom also alters the compound's stability and reactivity, impacting its kinetics in biochemical assays.

8-pCPT-cGMP, TEA is a selective cGMP analog that effectively activates cGMP-dependent protein kinase I (cGKI). The presence of the p-chlorophenyl group enhances its lipophilicity, promoting membrane permeability and facilitating rapid cellular uptake. This compound exhibits unique binding dynamics, stabilizing the cGKI conformation and influencing its enzymatic activity. Its distinct structural features also modulate reaction kinetics, allowing for precise control over signaling cascades.

8-Bromoguanosine 3', 5'-cyclic monophosphoric acid is a potent cGKI activator characterized by its brominated guanosine structure, which enhances its interaction with target proteins. The bromine atom introduces unique steric effects, influencing molecular conformation and binding affinity. This compound exhibits distinct allosteric modulation of cGKI, altering its phosphorylation dynamics and enabling fine-tuning of downstream signaling pathways. Its stability in aqueous environments further supports prolonged activity in cellular contexts.

Another PDE5 inhibitor similar in action to sildenafil. It's sold under various trade names like Levitra.

Yet another PDE5 inhibitor, which goes by the trade name Cialis. It has a longer half-life compared to sildenafil and vardenafil.

A soluble guanylyl cyclase (sGC) stimulator studied in the research of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). It increases cGMP levels by stimulating sGC.