cGKIα Antibody (F-5): sc-393987

cGKIα Antibody (F-5) is a mouse monoclonal IgM antibody that detects cGKI alpha protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-cGKI alpha antibody (F-5) is available as a non-conjugated format. cGKI alpha protein plays a crucial role in mediating various physiological responses by acting as a major receptor for intracellular cyclic guanosine monophosphate (cGMP). cGKI alpha protein is primarily located in the cytosol and is essential for the relaxation of vascular smooth muscle, as cGKI alpha protein lowers intracellular calcium levels. Proper functioning of cGKI alpha protein is vital for maintaining vascular tone and blood pressure regulation. Notably, cGKI alpha is one of two isoforms of cGKI, the other being cGKI beta, which differ only in their N-terminal sequences. Expression of cGKI alpha in tissues such as the brain, intestine, and prostate highlights cGKI alpha′s importance in diverse biological processes. cGKI alpha protein interacts with various signaling molecules, further underscoring cGKI alpha′s role in cellular signaling pathways. cGKI alpha monoclonal antibody (F-5) is an invaluable tool for researchers studying the intricate mechanisms of cGMP signaling and its implications in cardiovascular health and disease.

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cGKIα Antibody (F-5) References:

1. Cyclic GMP-dependent protein kinases: understanding in vivo functions by gene targeting.  |  Ruth, P. 1999. Pharmacol Ther. 82: 355-72. PMID: 10454212
2. Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action.  |  Francis, SH. and Corbin, JD. 1999. Crit Rev Clin Lab Sci. 36: 275-328. PMID: 10486703
3. Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha.  |  Surks, HK., et al. 1999. Science. 286: 1583-7. PMID: 10567269
4. The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms.  |  Gamm, DM., et al. 1995. J Biol Chem. 270: 27380-8. PMID: 7593002
5. cDNA cloning and gene expression of human type Ialpha cGMP-dependent protein kinase.  |  Tamura, N., et al. 1996. Hypertension. 27: 552-7. PMID: 8613202
6. Signalling by cGMP-dependent protein kinases.  |  Vaandrager, AB. and de Jonge, HR. Mol Cell Biochem. 157: 23-30. PMID: 8739225
7. Characterization of the human gene encoding the type I alpha and type I beta cGMP-dependent protein kinase (PRKG1).  |  Orstavik, S., et al. 1997. Genomics. 42: 311-8. PMID: 9192852

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cGKIα Antibody (F-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-cGKIα Antibody (F-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cGKIα Antibody (F-5) Specifications

Alternate Product Name: cGKIα

Product Clone Name: F-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 62-89

Epitope Target: cGKIα

Epitope Species: human

Product Reactivity/Detection: cGKIα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for cGKIα Antibody (F-5): P: Blocking Peptide