Date published: 2025-9-30

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8-Bromoguanosine 3′, 5′ -cyclic monophosphoric acid (CAS 31356-94-2)

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Alternate Names:
8-Br-CGMP
CAS Number:
31356-94-2
Molecular Weight:
424.1
Molecular Formula:
C10H11BrN5O7P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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This product is known to activate cGMP-dependent protein kinase. In human platelets, it has been shown to inhibit arachidonic acid release that is induced by thrombin. It has been reported to slow down or inhibit oscillations of intracellular calcium in response to acetylcholine in tracheal smooth muscle cells. It has been observed to mimic the effect of drugs that generate nitric oxide. It is membrane-permeable, and offers greater hydrolysis resistance by phosphodiesterases than cGMP.


8-Bromoguanosine 3′, 5′ -cyclic monophosphoric acid (CAS 31356-94-2) References

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  2. The modulation of spontaneous and anti-Ig-stimulated motility of lymphocytes by cyclic nucleotides and adrenergic and cholinergic agents.  |  Schreiner, GF. and Unanue, ER. 1975. J Immunol. 114: 802-8. PMID: 163280
  3. Inhibitory and enhancing effects of NO on H(2)O(2) toxicity: dependence on the concentrations of NO and H(2)O(2).  |  Rauen, U., et al. 2007. Free Radic Res. 41: 402-12. PMID: 17454122
  4. Activation of human B lymphocytes VII. the regulatory effect of cyclic adenosine monophosphate on human B cell activation.  |  Katz, P. and Fauci, AS. 1978. J Allergy Clin Immunol. 61: 334-8. PMID: 205567
  5. The molecular basis of neurotrophic keratitis.  |  Cavanagh, HD. and Colley, AM. 1989. Acta Ophthalmol Suppl (1985). 192: 115-34. PMID: 2554641
  6. Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation.  |  Dobbs, LG. and Mason, RJ. 1979. J Clin Invest. 63: 378-87. PMID: 34631
  7. Early biochemical events in lymphocyte activation. I. Investigations on the nature and significance of early calcium fluxes observed in mitogen-induced T and B lymphocytes.  |  Freedman, MH. 1979. Cell Immunol. 44: 290-313. PMID: 378421
  8. Regulation of secretion in Clara cells: studies using the isolated perfused rat lung.  |  Massaro, GD., et al. 1981. J Clin Invest. 67: 345-51. PMID: 6257761
  9. Surfactant secretion: evidence that cholinergic stimulation of secretion is indirect.  |  Massaro, D., et al. 1982. Am J Physiol. 243: C39-45. PMID: 6283907
  10. Studies on the mechanism of human natural killer cell-mediated cytolysis. I. Modulation by dexamethasone and arachidonic acid.  |  Bray, R., et al. 1983. Cell Immunol. 78: 100-13. PMID: 6303603
  11. Effect of chemical and pharmacological agents on the secretory activity induced by Escherichia coli heat-stable enterotoxin.  |  Knoop, FC. and Abbey, DM. 1981. Can J Microbiol. 27: 754-8. PMID: 6794896

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

8-Bromoguanosine 3′, 5′ -cyclic monophosphoric acid, 5 mg

sc-291685
5 mg
$116.00

8-Bromoguanosine 3′, 5′ -cyclic monophosphoric acid, 10 mg

sc-291685A
10 mg
$206.00