CGI-96 Inhibitors
CGI-96 inhibitors are a class of compounds designed to specifically inhibit the activity of the CGI-96 protein, a member of the large family of proteins involved in various cellular processes, including protein folding, trafficking, and cellular signaling. Although CGI-96 is not yet fully characterized, it is believed to play a role in maintaining cellular homeostasis, potentially through interactions with other proteins or involvement in complex intracellular pathways. By inhibiting CGI-96, these compounds prevent the protein from performing its normal functions, leading to alterations in the pathways it regulates. CGI-96 inhibitors allow researchers to probe the specific biological roles of this protein, offering insights into how its inhibition affects cellular processes such as protein stability, signaling pathways, and metabolic functions.
The mechanism of action for CGI-96 inhibitors involves binding to the protein and blocking its interaction with other molecular partners or its active site, which hinders its function. This inhibition helps researchers understand the direct and downstream effects of CGI-96 disruption, particularly in terms of protein management within the cell and other related processes. CGI-96 inhibitors serve as valuable tools for studying the broader impacts of inhibiting this protein, allowing scientists to observe changes in cellular behavior, molecular organization, and homeostasis. By modulating the activity of CGI-96, researchers can gain a deeper understanding of the protein's role in maintaining normal cellular functions and how its regulation affects key biochemical pathways that ensure proper cellular operation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can enhance ribosomal RNA synthesis, which may indirectly increase the demand for RRP7A function in rRNA processing. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences cell differentiation and may increase nucleolar activity, potentially enhancing RRP7A-mediated rRNA processing. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
By inhibiting dihydrofolate reductase, Methotrexate leads to a build-up of ribonucleotide pools, which can indirectly necessitate increased RRP7A activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
By binding to DNA, Actinomycin D inhibits rRNA synthesis transiently, which may lead to compensatory mechanisms enhancing RRP7A activity. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide affects transcription factors and could enhance RRP7A activity by upregulating nucleolar processes. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
Leptomycin B inhibits nuclear export, potentially increasing nuclear retention of rRNA, which may require enhanced RRP7A function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, Rapamycin can modulate ribosome biogenesis, potentially influencing RRP7A activity indirectly. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
BMH-21 binds RNA polymerase I, leading to degradation of the enzyme and potentially enhancing compensatory rRNA processing involving RRP7A. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $110.00 $386.00 | 8 | |
Oxaliplatin induces cellular stress responses, which can include upregulation of nucleolar functions, potentially enhancing RRP7A activity. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A has been shown to affect gene expression and might indirectly enhance RRP7A function as part of a stress response. | ||||||