CFTR Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a natural isoflavone, potentiates CFTR channel activity by increasing its open probability. | ||||||
Ivacaftor | 873054-44-5 | sc-364679 | 5 mg | $259.00 | ||
Ivacaftor is a CFTR potentiator that enhances the activity of CFTR channels at the cell surface, increasing chloride transport. | ||||||
1-EBIO | 10045-45-1 | sc-201695 sc-201695A | 10 mg 50 mg | $87.00 $325.00 | 1 | |
1-EBIO is a notable compound recognized for its ability to modulate ion channel activity, particularly in the CFTR pathway. Its unique structure enhances its affinity for specific binding sites, promoting conformational changes that facilitate chloride ion transport. The compound's hydrophobic regions contribute to its membrane permeability, while its interactions with lipid bilayers can influence cellular signaling pathways. This behavior underscores its role in altering ion homeostasis in various biological contexts. | ||||||
VX 809 | 936727-05-8 | sc-474670 | 10 mg | $592.00 | ||
VX 809 is a CFTR corrector. It helps in trafficking mutant CFTR protein to the cell surface, increasing its availability for activation. | ||||||
2-Pyridin-4-yl-benzo[h]chromen-4-one | 2110-25-0 | sc-308653 | 1 g | $378.00 | ||
2-Pyridin-4-yl-benzo[h]chromen-4-one is a CFTR potentiator that increases chloride transport by enhancing CFTR channel activity. | ||||||
Aloisine A | 496864-16-5 | sc-202451 | 1 mg | $62.00 | ||
Aloisine A is a distinctive compound that exhibits remarkable interactions with the CFTR channel, influencing its gating mechanisms. Its structural features allow for selective binding to regulatory sites, which can stabilize the open conformation of the channel. The compound's unique electron-donating groups enhance its reactivity, facilitating rapid kinetics in ion transport processes. Additionally, its amphiphilic nature aids in modulating membrane dynamics, impacting cellular ion balance and signaling pathways. | ||||||
PTC124 | 775304-57-9 | sc-203222 sc-203222A | 2 mg 5 mg | $203.00 $416.00 | 2 | |
Ataluren promotes ribosomal read-through of premature stop codons in CFTR mRNA, producing a functional CFTR protein. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Phenylbutyrate acts as a CFTR corrector by enhancing the expression and maturation of the CFTR protein. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can restore the function of certain CFTR mutations, though its exact mechanism is not well-defined. | ||||||
Adenosine phosphate(Vitamin B8) | 61-19-8 | sc-278678 sc-278678A | 50 g 100 g | $160.00 $240.00 | ||
5'-AMP activates CFTR-mediated chloride secretion by increasing cAMP levels in the cell. | ||||||