Molecular structure of Aloisine A, CAS Number: 496864-16-5
Aloisine A (CAS 496864-16-5)
Alternate Names:
RP107; 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
Application:
Aloisine A is an inhibitor of CDK1, CDK2, CDK5, GSK-3 alpha, and JNK
CAS Number:
496864-16-5
Purity:
≥95%
Molecular Weight:
267.33
Molecular Formula:
C16H17N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Aloisine A is a highly potent and selective inhibitor of CDK (cyclin-dependent kinase) and GSK-3 (glycogen synthase kinase-3). Its inhibitory action effectively halts cell proliferation by arresting cells in both the G1 and G2 phases of the cell cycle. By blocking specific cell cycle checkpoints, it significantly disrupts cell proliferation in both the G1 and G2 phases. Moreover, its ability to inhibit GSK-3β and JNK further expands its impact on important signaling pathways.
Aloisine A (CAS 496864-16-5) References
- Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects. | Mettey, Y., et al. 2003. J Med Chem. 46: 222-36. PMID: 12519061
- Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors. | Collins, I. and Garrett, MD. 2005. Curr Opin Pharmacol. 5: 366-73. PMID: 15964238
- Novel 5,7-disubstituted 6-amino-5H-pyrrolo[3,2-b]pyrazine-2,3-dicarbonitriles, the promising protein kinase inhibitors with antiproliferative activity. | Dubinina, GG., et al. 2006. Eur J Med Chem. 41: 727-37. PMID: 16675067
- Discovery of pyrrolo[2,3-b]pyrazines derivatives as submicromolar affinity activators of wild type, G551D, and F508del cystic fibrosis transmembrane conductance regulator chloride channels. | Noel, S., et al. 2006. J Pharmacol Exp Ther. 319: 349-59. PMID: 16829626
- Identification of potential cellular targets of aloisine A by affinity chromatography. | Corbel, C., et al. 2009. Bioorg Med Chem. 17: 5572-82. PMID: 19596197
- Compounds that target host cell proteins prevent varicella-zoster virus replication in culture, ex vivo, and in SCID-Hu mice. | Rowe, J., et al. 2010. Antiviral Res. 86: 276-85. PMID: 20307580
- Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro. | Zahler, S., et al. 2010. Angiogenesis. 13: 239-49. PMID: 20706783
- Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations. | Rivest, P., et al. 2011. Chem Biol Interact. 189: 177-85. PMID: 21111724
- Stimulation of Wild-Type, F508del- and G551D-CFTR Chloride Channels by Non-Toxic Modified pyrrolo[2,3-b]pyrazine Derivatives. | Dannhoffer, L., et al. 2011. Front Pharmacol. 2: 48. PMID: 21897819
- Kinase control prevents HIV-1 reactivation in spite of high levels of induced NF-κB activity. | Wolschendorf, F., et al. 2012. J Virol. 86: 4548-58. PMID: 22345467
- Proliferation rate of somatic cells affects reprogramming efficiency. | Xu, Y., et al. 2013. J Biol Chem. 288: 9767-9778. PMID: 23439651
- Binding Mechanism of Inhibitors to CDK5/p25 Complex: Free Energy Calculation and Ranking Aggregation Analysis. | Wu, Q., et al. 2013. Mol Inform. 32: 251-60. PMID: 27481520
- Rapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction. | Bulutoglu, B., et al. 2019. Sci Rep. 9: 15848. PMID: 31676845
Inhibitor of:
Cdk2, Cdk5, GSK-3 alpha, JNK, and Ser/Thr Protein Kinase.Activator of:
CFTR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aloisine A, 1 mg | sc-202451 | 1 mg | $62.00 |