CEP135 Activators
Common CEP135 Activators include, but are not limited to Taxol CAS 33069-62-4, Docetaxel CAS 114977-28-5, Griseofulvin CAS 126-07-8, RO-3306 CAS 872573-93-8 and Roscovitine CAS 186692-46-6.
CEP135, also known as Centrosomal Protein 135, is a protein that plays a crucial role in centrosome biology. Located primarily in the centrosome of cells, CEP135 is vital for centrosome cohesion and separation, ensuring the proper division and multiplication of cells. As a core component of the centrosome, it is involved in regulating the assembly of other centrosomal proteins and ensuring the correct formation of microtubule-organizing centers, which are pivotal for cellular structure and division processes. Given its significance in cellular dynamics, the regulation of CEP135's activity becomes paramount.
Activators of CEP135 are chemical entities or agents that promote or enhance the function or expression of the CEP135 protein. These activators can potentially influence the cellular localization, stability, or interactions of CEP135 within the cell. By augmenting CEP135's activity, these activators can potentially impact various cellular processes, especially those associated with centrosome dynamics, cell cycle progression, and microtubule organization. The exact mechanisms by which these activators operate could range from direct binding to CEP135, enhancing its stability or promoting its interactions with other proteins, to indirect mechanisms that increase its transcription or translation. It is also possible that such activators work in synergy with other cellular components to modulate CEP135's functions. As our understanding of centrosome biology and the role of CEP135 deepens, the importance and potential applications of CEP135 activators will likely become more evident, offering new insights into cellular dynamics and the intricate world of cell division and structure.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and prevents their depolymerization, which is crucial for mitotic spindle formation and chromosome segregation. Given CEP135's role in centriole biogenesis and microtubule binding, Paclitaxel might influence CEP135 expression or function in centriole formation. | ||||||
Docetaxel | 114977-28-5 | sc-201436 sc-201436A sc-201436B | 5 mg 25 mg 250 mg | $87.00 $332.00 $1093.00 | 16 | |
Similar to paclitaxel, Docetaxel is a microtubule stabilizer that could potentially influence CEP135 expression or function, given CEP135's role in microtubule binding and centriole formation. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts mitotic spindle formation, potentially impacting centriole function. Given CEP135's critical role in centriole biogenesis, this compound might indirectly affect CEP135 expression or function. | ||||||
RO-3306 | 872573-93-8 | sc-358700 sc-358700A sc-358700B | 1 mg 5 mg 25 mg | $66.00 $163.00 $326.00 | 37 | |
As a CDK1 inhibitor affecting the G2-M checkpoint, RO-3306 could potentially impact CEP135 function during early S phase centriole recruitment, possibly affecting CEP135 expression as a consequence. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a CDK inhibitor affecting cell cycle progression, which might have an impact on CEP135 expression given CEP135's pivotal role in centriole biogenesis and cell cycle regulation. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib is another CDK inhibitor impacting cell cycle regulation. Given CEP135's role in centriole biogenesis, which is crucial for cell division, Palbociclib might potentially influence CEP135 expression or function. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is known to inhibit the NF-κB pathway. Given previous associations between CEP135 and the NF-κB pathway, Resveratrol might indirectly influence CEP135 expression through modulating this pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin also modulates the NF-κB pathway, which might indirectly influence CEP135 expression. Given CEP135's role in centriole biogenesis, modulating pathways affecting cell proliferation and survival might impact CEP135 expression. | ||||||