CEP135 Inhibitors
CEP135 inhibitors represent a specialized class of chemical compounds designed to specifically impede the function of the CEP135 protein, a crucial component in the centrosome structure of eukaryotic cells. CEP135 is a centrosomal protein that plays a significant role in centriole assembly and stability, which are key elements of the cytoskeletal organization and are essential for proper cell division. The inhibition of CEP135 disrupts the integrity of centrioles, leading to defects in spindle formation during mitosis. This class of inhibitors achieves its effects through direct interaction with the CEP135 protein, blocking its ability to participate in centrosomal cohesion and microtubule nucleation. By doing so, CEP135 inhibitors undermine the foundational structures that are necessary for the centrosome to function as a microtubule-organizing center, which is critical for the successful segregation of chromosomes during cell division.
The mechanism of action of CEP135 inhibitors is defined by their ability to bind with the CEP135 protein at specific domains, preventing its interaction with other centrosomal proteins such as CPAP or STIL, which are necessary for centriole biogenesis and maintenance. This disruption can result in the malformation of centrioles, causing aberrant mitotic spindle assembly and consequently, cell cycle arrest. The specificity of these inhibitors lies in their targeted approach, which allows them to selectively inhibit CEP135 function without affecting the broader cellular processes. This precision underscores the fine balance that cellular components like CEP135 maintain to ensure orderly cell division and highlights the intricate nature of cellular machinery. By blocking the functional domains of CEP135, these inhibitors serve as a tool for dissecting the complex pathways of centrosome composition and function, providing insight into the elaborate regulatory systems that govern cell division and the maintenance of genomic stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their depolymerization, which is essential for mitotic spindle formation. CEP135 is a centrosomal protein that is critical for microtubule assembly. Therefore, paclitaxel's action can lead to the functional inhibition of CEP135. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, thereby disrupting mitotic spindle formation. As CEP135 is involved in spindle assembly by contributing to centrosome cohesion, colchicine effectively inhibits CEP135 function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that interferes with microtubule dynamics. Given that CEP135 plays a role in centrosome function, nocodazole indirectly leads to the inhibition of CEP135 by disrupting the microtubules it helps organize. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation. By preventing microtubule assembly, vinblastine indirectly inhibits CEP135's role in centrosome and spindle function during cell division. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with microtubule proteins. This disruption can indirectly inhibit CEP135 by affecting the microtubule structures that are critical for CEP135's role in cell division. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits the polymerization of tubulin into microtubules. By blocking microtubule assembly, it can hinder the function of CEP135, which is involved in the formation and maintenance of the centrosome structure. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor that disrupts mitotic spindle pole assembly. Since CEP135 is crucial for proper spindle function, inhibiting spindle pole assembly indirectly inhibits the function of CEP135. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole interferes with microtubule polymerization. The inhibition of microtubule assembly indirectly affects the function of CEP135, which is crucial for the integrity of the centrosome and microtubule nucleation. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $68.00 $162.00 $318.00 $947.00 $1893.00 $6840.00 | 7 | |
Demecolcine binds to tubulin dimers and inhibits their polymerization. This action disrupts microtubule dynamics, indirectly leading to the inhibition of CEP135, as it is important for centrosome-mediated microtubule nucleation and stability. | ||||||