Centaurin α1 Activators
Centaurin alpha 1 (CENTA1), also known as ADP-ribosylation factor guanine nucleotide-exchange factor 1 (ARFGEF1), is a protein that in humans is encoded by the CENTA1 gene. It is part of the centaurin family of proteins, which are characterized by the presence of a characteristic pleckstrin homology (PH) domain and an Arf-GAP domain.CENTA1 functions as a guanine nucleotide exchange factor (GEF) for ADP ribosylation factors (ARFs), which are small GTP-binding proteins involved in vesicle trafficking and actin remodeling. By activating ARFs, CENTA1 can influence these processes, playing a key role in intracellular trafficking and cellular morphogenesis.
The PH domain of CENTA1 allows it to bind phospholipids, and it's thought to help target the protein to specific cellular locations, such as the plasma membrane. Meanwhile, the Arf-GAP domain provides GTPase activating protein (GAP) activity, turning off ARF signaling.given its involvement in critical cellular processes, it's plausible that dysfunction of CENTA1 could contribute to various pathological conditions. For example, disruptions in vesicle trafficking can contribute to neurological disorders and cancer.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, which might influence processes regulated by Centaurin α1/AGAP2. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide stabilizes actin filaments and could impact actin dynamics regulated by Centaurin α1/AGAP2. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Phalloidin binds and stabilizes actin filaments, potentially affecting Centaurin α1/AGAP2-mediated actin regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases cAMP levels, which can modulate various signaling pathways, potentially influencing Centaurin α1/AGAP2. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A disrupts actin polymerization, which might indirectly affect processes regulated by Centaurin α1/AGAP2. | ||||||
SU 6668 | 252916-29-3 | sc-204309 sc-204309A | 10 mg 50 mg | $127.00 $712.00 | 2 | |
ML141 is a Cdc42 inhibitor, potentially influencing pathways where Centaurin α1/AGAP2 is involved in actin dynamics. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor, potentially affecting signaling pathways relevant to Centaurin α1/AGAP2. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is an Arp2/3 complex inhibitor, impacting actin polymerization and potentially processes involving Centaurin α1/AGAP2. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a ROCK inhibitor, potentially affecting actin cytoskeleton dynamics relevant to Centaurin α1/AGAP2. | ||||||