Molecular structure of SU 6668, CAS Number: 252916-29-3
SU 6668 (CAS 252916-29-3)
See product citations (2)
Alternate Names:
3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; Orantinib; 3-[2, 4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl] propanoic acid
Application:
SU 6668 is an antiproliferating agent and ATP-competitive PDGFR, Flk-1/KDR (VEGF), and FGFR inhibitor
CAS Number:
252916-29-3
Purity:
>98%
Molecular Weight:
310.35
Molecular Formula:
C18H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100 μM at PDGFRβ, VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo. Shows antiangiogenic, anti-inflammatory, antimetastatic and proapototic activity and is orally active.
SU 6668 (CAS 252916-29-3) References
- Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. | Sun, L., et al. 1999. J Med Chem. 42: 5120-30. PMID: 10602697
- Kinase insert domain-containing receptor kinase inhibitors as anti-angiogenic agents. | Hartman, GD., et al. 2002. Expert Opin Investig Drugs. 11: 737-45. PMID: 12036418
- Antiangiogenic therapy through copper chelation. | Sproull, M., et al. 2003. Expert Opin Ther Targets. 7: 405-9. PMID: 12783576
- American Association for Cancer Research 1999: 10-14 April, Philadelphia, Pennsylvania. | Lavelle, F. 1999. Expert Opin Investig Drugs. 8: 903-9. PMID: 15992139
- TSU-68 (SU6668) inhibits local tumor growth and liver metastasis of human colon cancer xenografts via anti-angiogenesis. | Yorozuya, K., et al. 2005. Oncol Rep. 14: 677-82. PMID: 16077974
- MicroRNA-198 inhibits proliferation and induces apoptosis by directly suppressing FGFR1 in gastric cancer. | Gu, J., et al. 2019. Biosci Rep. 39: PMID: 31138759
- [FGFR-targeted therapy in head and neck carcinomas]. | Dietrich, D. 2021. HNO. 69: 172-184. PMID: 32519203
- A high-throughput 384-well CometChip platform reveals a role for 3-methyladenine in the cellular response to etoposide-induced DNA damage. | Li, J., et al. 2022. NAR Genom Bioinform. 4: lqac065. PMID: 36110898
- Novel 3-Methyleneisoindolinones Diversified via Intramolecular Heck Cyclization Induce Oxidative Stress, Decrease Mitochondrial Membrane Potential, Disrupt Cell Cycle, and Induce Apoptosis in Head and Neck Squamous Cell Carcinoma Cells. | Sharma, A., et al. 2022. ACS Omega. 7: 45036-45044. PMID: 36530328
Inhibitor of:
E130203B14Rik, FGFR, Flg, Flk-1, PDGF-B, and PDGFR-beta.Activator of:
ARAP1, Centaurin α1, CLK4, and Gα 13.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU 6668, 10 mg | sc-204309 | 10 mg | $127.00 | |||
SU 6668, 50 mg | sc-204309A | 50 mg | $712.00 |