CENP-S Inhibitors
CENP-S Inhibitors represent a category of chemical compounds designed to selectively impede the activity of the CENP-S protein. CENP-S, which stands for Centromere Protein S, is a component of the centromere, a crucial region of the chromosome involved in cell division and ensuring the accurate segregation of genetic material. The development of inhibitors targeting CENP-S is integral to scientific investigations, serving as specialized tools to unravel the intricacies of its molecular functions within the context of cellular processes. As part of the larger network of centromeric proteins, CENP-S plays a role in the assembly of the kinetochore, a structure essential for proper chromosome segregation during mitosis.
The synthesis and optimization of CENP-S inhibitors necessitate a comprehensive understanding of the protein's structural characteristics and its involvement in cellular mechanisms. These inhibitors are meticulously crafted to specifically interact with key regions of CENP-S, disrupting its normal biochemical activities. By utilizing these inhibitory compounds in experimental settings, researchers can investigate the consequences of CENP-S inhibition on the dynamics of centromeric functions, shedding light on the protein's role in maintaining genomic stability. The study of CENP-S inhibitors contributes to the broader exploration of cell division processes, providing insights into the intricate molecular machinery that governs accurate chromosome segregation and supporting a deeper comprehension of the fundamental aspects of cellular biology.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and can inhibit RNA polymerase, potentially decreasing the transcription of many genes, including possibly CENPS. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic ribosomes, leading to a general decrease in protein synthesis, affecting various proteins including potentially CENPS. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Blocks the mTOR signaling pathway which is involved in cell growth and protein synthesis, possibly reducing the expression of CENPS. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A cytidine analog that can induce DNA demethylation, potentially altering the expression of a wide range of genes. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that can change chromatin structure and broadly affect gene expression patterns. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
Selectively inhibits RNA polymerase II, and this could lead to decreased mRNA synthesis for a variety of genes. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
Inhibits inosine monophosphate dehydrogenase and could affect nucleotide synthesis, impacting RNA and DNA synthesis. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Inhibits protein synthesis by blocking peptide bond formation on ribosomes, which could decrease overall protein levels. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, which is necessary for DNA replication and transcription processes, potentially affecting gene expression. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
Inhibits RNA polymerase II, which could decrease the primary synthesis of mRNA for various genes. | ||||||