CENP-A Activators
CENP-A Activators refer to compounds known to modulate the activity or expression of CENP-A, a variant of histone H3, integral to the formation of centromeres in cells. This category of chemicals primarily encompasses agents that alter chromatin structures and influence epigenetic modulation, subsequently affecting the incorporation and function of CENP-A in the chromatin. For instance, 5-Azacytidine and Decitabine modify DNA methylation, impacting the epigenetic landscape, which can have a bearing on CENP-A activity and its role in centromere formation and function. Additionally, compounds like Trichostatin A, Sodium Butyrate, Vorinostat, and Valproic Acid are recognized for their capability to inhibit histone deacetylases (HDAC), causing alterations in chromatin structure, potentially influencing the interaction and integration of CENP-A within chromatin.
Further, chemicals like Romidepsin, Entinostat, Mocetinostat, Panobinostat, and SAHA continue the trend of HDAC inhibition, each contributing to changes in chromatin state and thereby, indirectly impacting CENP-A activity and expression. The modifications induced by these compounds may alter the dynamics of CENP-A incorporation into centromeres, influencing the stability and function of the centromeric chromatin. Azacitidine is another agent affecting DNA methylation, providing another layer of epigenetic modification, affecting CENP-A's role within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Affects DNA methylation and might influence CENP-A activity through epigenetic modulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Alters chromatin structure by inhibiting histone deacetylase, influencing CENP-A incorporation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Modifies chromatin and impacts CENP-A activity by inhibiting histone deacetylases. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Affects CENP-A expression by altering chromatin structure through HDAC inhibitory activity. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Influences CENP-A through HDAC inhibitory properties, altering chromatin structure. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Influences CENP-A activity by modifying chromatin states through HDAC inhibition. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $90.00 $212.00 | 24 | |
Impacts CENP-A expression through alterations in chromatin states by inhibiting HDAC. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
Affects CENP-A activity indirectly through influence on chromatin structure as an HDAC inhibitor. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $200.00 | 9 | |
Alters chromatin structure and potentially influences CENP-A through HDAC inhibitory activity. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Influences CENP-A through DNA hypomethylation, impacting epigenetic modulation. | ||||||