Cell Cycle Arresting Compounds
Items 81 to 90 of 170 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retrorsine | 480-54-6 | sc-215805 sc-215805A sc-215805B sc-215805C sc-215805D sc-215805E | 100 mg 500 mg 1 g 2 g 3 g 5 g | $256.00 $935.00 $1750.00 $3468.00 $5100.00 $8160.00 | 3 | |
Retrorsine is a pyrrolizidine alkaloid that exerts its effects on the cell cycle by disrupting microtubule dynamics, leading to mitotic arrest. It interferes with spindle formation, causing aberrant chromosome segregation. Additionally, Retrorsine activates specific stress response pathways, which can enhance cellular senescence. Its unique ability to induce DNA damage through reactive oxygen species generation further underscores its role in halting cell cycle progression, making it a potent agent in cellular regulation. | ||||||
Hinokitiol | 499-44-5 | sc-200812 sc-200812A sc-200812B sc-200812C sc-200812D sc-200812E | 50 mg 250 mg 1 g 10 g 50 g 100 g | $63.00 $193.00 $357.00 $714.00 $1533.00 $2244.00 | ||
Hinokitiol is a natural compound that influences the cell cycle by modulating key signaling pathways involved in cell proliferation. It interacts with various cellular targets, leading to the activation of checkpoint proteins that halt progression through the cell cycle. This compound also exhibits antioxidant properties, which can mitigate oxidative stress and influence cellular responses. Its ability to induce apoptosis in specific cell types further highlights its role in regulating cellular growth and division. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
L-Mimosine is a plant-derived compound that disrupts the cell cycle by chelating essential metal ions, particularly iron, which is crucial for DNA synthesis and cellular division. This interaction leads to the inhibition of ribonucleotide reductase, effectively stalling the S phase of the cell cycle. Additionally, L-Mimosine can induce oxidative stress, triggering cellular signaling pathways that promote cell cycle arrest and apoptosis in susceptible cells. Its unique mechanism underscores its potential as a regulatory agent in cellular processes. | ||||||
(±)-Hesperetin | 520-33-2 | sc-202647 | 1 g | $46.00 | 4 | |
(±)-Hesperetin is a flavonoid that influences cell cycle dynamics by modulating key signaling pathways, particularly those involving cyclin-dependent kinases (CDKs). It exhibits a unique ability to enhance the expression of cell cycle inhibitors, such as p21, leading to G1 phase arrest. Furthermore, (±)-Hesperetin can induce reactive oxygen species (ROS) production, which activates stress response pathways, ultimately contributing to cell cycle regulation and growth inhibition. Its multifaceted interactions highlight its role in cellular homeostasis. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol is a compound that influences cell cycle progression by engaging with various molecular targets, particularly affecting the expression of genes involved in cell cycle regulation. It promotes the upregulation of tumor suppressor proteins and downregulates oncogenes, leading to G1 phase arrest. Additionally, it can modulate the activity of histone deacetylases, altering chromatin structure and gene expression, which further impacts cellular proliferation and survival pathways. | ||||||
IMD 0354 | 978-62-1 | sc-203084 | 5 mg | $199.00 | 3 | |
IMD 0354 is a selective inhibitor that disrupts specific signaling pathways critical for cell cycle progression. By targeting key kinases, it effectively halts the transition from G1 to S phase, leading to cell cycle arrest. Its unique ability to modulate protein interactions within the cell cycle machinery results in altered phosphorylation states of regulatory proteins. This compound's kinetic profile allows for precise control over cellular responses, making it a significant player in cell cycle dynamics. | ||||||
Dexamethasone Acetate | 1177-87-3 | sc-204714 sc-204714A | 100 mg 500 mg | $57.00 $120.00 | 1 | |
Dexamethasone Acetate functions as a potent cell cycle arresting agent by influencing the expression of cyclins and cyclin-dependent kinases. Its unique structural features enable it to bind selectively to glucocorticoid receptors, modulating transcriptional activity that governs cell proliferation. This compound's interaction with chromatin remodeling complexes alters gene expression patterns, effectively stalling cell cycle progression and promoting apoptosis in specific cellular contexts. | ||||||
N-4-Tosyl-L-arginine methyl ester hydrochloride | 1784-03-8 | sc-207949 sc-207949A | 5 g 25 g | $40.00 $118.00 | 1 | |
N-4-Tosyl-L-arginine methyl ester hydrochloride acts as a cell cycle arresting compound by selectively inhibiting proteolytic enzymes involved in cell cycle regulation. Its unique tosyl group enhances binding affinity to target proteins, disrupting critical signaling pathways. This compound's ability to modulate post-translational modifications influences the activity of cell cycle regulators, leading to a halt in cellular proliferation and promoting a state of quiescence in susceptible cell types. | ||||||
Cytochalasin A | 14110-64-6 | sc-204705 sc-204705A sc-204705B | 1 mg 5 mg 10 mg | $105.00 $277.00 $456.00 | 1 | |
Cytochalasin A functions as a cell cycle arresting compound by disrupting actin polymerization, which is crucial for maintaining cytoskeletal integrity. This compound binds to the barbed ends of actin filaments, preventing their elongation and thereby interfering with cellular processes such as mitosis and cytokinesis. Its unique mechanism of action leads to the inhibition of cell motility and division, effectively halting progression through the cell cycle and inducing a state of cellular stasis. | ||||||
Perillic Acid | 23635-14-5 | sc-200841 sc-200841A | 100 mg 500 mg | $46.00 $196.00 | ||
Perillic acid acts as a cell cycle arresting compound by modulating key signaling pathways involved in cell proliferation. It interacts with specific enzymes, influencing the phosphorylation states of proteins that regulate the cell cycle checkpoints. This compound can induce G1 phase arrest by altering cyclin-dependent kinase activity, thereby preventing the transition to the S phase. Its unique ability to disrupt cellular signaling cascades contributes to its effectiveness in halting cell division. | ||||||