CED-5 Activators
CED-5 activators encompass a range of compounds that indirectly influence the activity of CED-5/Dock180 by modulating the Rac1 GTPase signaling pathway and actin cytoskeleton dynamics. These compounds exert their effects by either stabilizing actin filaments, inhibiting related GTPases, or altering the activity of other proteins that regulate GTPases, which can lead to a compensatory upregulation of CED-5/Dock180 activity. For instance, actin filament stabilizers like Jasplakinolide, or disruptors such as Swinholide A, can initiate cellular responses that enhance the activity of Dock180 as the cell attempts to regulate its cytoskeletal architecture.
Furthermore, small molecule such as NSC23766, and ML141, do not directly activate CED-5 but modulate the activity of Rac1 and related GTPases, thereby indirectly impacting CED-5's function. The indirect effects of these compounds may result in altered signaling dynamics that engage Dock180, given its role in actin cytoskeletal remodeling and cell engulfment processes. Inhibition of other GEFs or downstream effectors, as seen with EHop-016, LY294002, and IPA-3, might create a cellular environment where Dock180's GEF activity is upregulated to maintain homeostasis within the actin cytoskeleton and associated signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and can result in the activation of signaling pathways that compensate by activating Rac1, thereby enhancing Dock180-ELMO activity. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
Inhibits Rac1-specific GEFs, the inhibition of which can result in a compensatory upregulation of other GEFs like Dock180. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
Inhibitor of Cdc42, another Rho GTPase, whose inhibition can lead to compensatory activation of Rac1 pathways, potentially enhancing Dock180 activity. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
Inhibits Vav2, a GEF for Rac1, leading to possible compensatory upregulation of Dock180 activity. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
ROCK inhibitor that can increase GTPase activity of Rac1, potentially affecting Dock180 activation due to its role as a Rac1 GEF. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Inhibits N-WASP, a regulator of actin polymerization; inhibition can lead to enhanced Rac1 activity and thereby Dock180 engagement. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
Inhibits PAK, a downstream effector of Rac1; inhibition might lead to feedback activation of Rac1 signaling and Dock180. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
Disrupts Cdc42 and its effector interaction, which might enhance Rac1 signaling and Dock180's role as a Rac1 GEF. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Actin filament disruptor that may trigger compensatory Rac1 activation and thus influence Dock180 function. | ||||||