Cdk8 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol functions as a selective inhibitor of Cdk8, exhibiting unique binding characteristics through a combination of hydrophobic and electrostatic interactions. Its structural conformation allows for effective competition with ATP, thereby modulating kinase activity. This compound influences transcriptional regulation by altering the phosphorylation state of target proteins, impacting downstream signaling pathways. Additionally, its kinetic profile reveals a distinct mechanism of action that can fine-tune cellular responses. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB acts as a potent inhibitor of Cdk8, characterized by its ability to disrupt the kinase's interaction with cyclin partners. This compound selectively alters the phosphorylation dynamics of transcription factors, leading to significant changes in gene expression. Its unique binding affinity is attributed to specific hydrogen bonding and hydrophobic interactions, which stabilize the inhibitor-kinase complex. Furthermore, DRB's influence on transcriptional elongation highlights its role in modulating RNA polymerase II activity, showcasing its impact on cellular transcriptional landscapes. | ||||||
H-8 • 2HCL | 113276-94-1 | sc-200526 sc-200526A | 10 mg 50 mg | $60.00 $250.00 | 3 | |
H-8 • 2HCl serves as a selective inhibitor of Cdk8, effectively modulating its kinase activity through unique molecular interactions. This compound engages in specific electrostatic and van der Waals forces, enhancing its binding affinity to the enzyme. By altering the phosphorylation state of target proteins, it influences critical signaling pathways. Additionally, H-8 • 2HCl's role in regulating transcriptional machinery underscores its potential to reshape cellular responses to various stimuli. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a broad-spectrum CDK inhibitor that targets CDK8, among others, and blocks cell cycle progression by inhibiting CDK-mediated phosphorylation of cell cycle proteins. | ||||||
THZ1 | 1604810-83-4 | sc-507542 | 1 mg | $95.00 | ||
THZ1 is a covalent CDK7/CDK12/CDK13 inhibitor that indirectly impacts CDK8 by inhibiting its transcription-regulating partners CDK7/CDK12/CDK13 in the Mediator complex. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
LGK 974 is a potent and specific inhibitor of the Wnt/β-catenin pathway by targeting CDK8-mediated phosphorylation of β-catenin, thereby impacting transcriptional activity. | ||||||
RGB-286638 | 784210-88-4 | sc-507523 | 250 mg | $285.00 | ||
RGB-286638 is a selective CDK8 inhibitor that attenuates Wnt/β-catenin signaling by inhibiting CDK8-mediated phosphorylation of β-catenin, thereby modulating transcriptional output. | ||||||