Date published: 2025-11-4

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Cdk2 Activators

Cyclin-dependent kinase 2 (Cdk2) activators belong to a class of small molecules that play a pivotal role in regulating the cell cycle and are instrumental in governing various cellular processes. Cdk2 is a member of the cyclin-dependent kinase family, which operates in conjunction with specific regulatory proteins called cyclins to modulate the progression of the cell cycle. Cdk2, when appropriately activated, orchestrates the transition from the G1 phase to the S phase of the cell cycle, allowing DNA replication to occur. Consequently, Cdk2 activators are compounds that stimulate the kinase activity of Cdk2, promoting its association with cyclins and facilitating the phosphorylation of critical substrates involved in cell cycle progression. These activators can operate through diverse mechanisms. Some Cdk2 activators function by enhancing the binding of Cdk2 to its cognate cyclin partner, thereby forming an active holoenzyme complex. This complex then phosphorylates target proteins such as retinoblastoma protein (Rb), releasing transcription factors necessary for the expression of genes required for DNA synthesis and cell division. Other activators may act indirectly by influencing the expression or stability of cyclins that partner with Cdk2, ensuring the availability of functional kinase complexes at specific cell cycle checkpoints. The precise mechanisms by which Cdk2 activators operate can vary, reflecting the complexity of cell cycle regulation and the need for tight control over critical cellular processes.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

6-Benzylaminopurine

1214-39-7sc-202428
sc-202428A
1 g
5 g
$20.00
$51.00
(1)

A synthetic cytokinin mainly utilized in plant biology. It's been reported to induce Cdk2 activation in plant cells, likely through its role in promoting cell division and DNA replication.

Olomoucine

101622-51-9sc-3509
sc-3509A
5 mg
25 mg
$72.00
$274.00
12
(1)

Predominantly a Cdk inhibitor, its mechanism largely involves inhibiting cyclin-dependent kinases, including Cdk2. However, in specific cellular contexts or concentrations, it might indirectly modulate Cdk2 activation.

Roscovitine

186692-46-6sc-24002
sc-24002A
1 mg
5 mg
$92.00
$260.00
42
(2)

Like Olomoucine, Roscovitine is primarily a Cdk inhibitor. Its nuanced effects on Cdk2 activation depend on the cellular context, but its primary mechanism involves inhibiting cyclin-dependent kinases.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$285.00
$520.00
$1300.00
78
(4)

A potent inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, Okadaic acid can prevent the dephosphorylation of certain proteins, possibly including those involved in Cdk2 regulation, leading to altered Cdk2 activation.

Caffeine

58-08-2sc-202514
sc-202514A
sc-202514B
sc-202514C
sc-202514D
5 g
100 g
250 g
1 kg
5 kg
$32.00
$66.00
$95.00
$188.00
$760.00
13
(1)

Widely recognized for its role in adenosine receptor antagonism, caffeine also affects several kinases and phosphatases. Through these interactions, caffeine might indirectly modulate Cdk2 activation.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$26.00
$92.00
$120.00
$310.00
$500.00
$908.00
$1821.00
46
(1)

A tyrosine kinase inhibitor known to influence various cellular signaling pathways. Through its broad range of effects, Genistein could potentially modulate Cdk2 activity, although the connection is indirect.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

An anti-cancer drug causing DNA damage, thereby influencing cell cycle checkpoints. In response to DNA damage, cells might adjust Cdk2 activity to manage cell cycle progression.

L-Mimosine

500-44-7sc-201536A
sc-201536B
sc-201536
sc-201536C
25 mg
100 mg
500 mg
1 g
$35.00
$86.00
$216.00
$427.00
8
(2)

An alkaloid that induces G1 arrest. By affecting progression through the G1 phase of the cell cycle, Mimosine might indirectly modulate Cdk2 activity, which is crucial for the G1-to-S phase transition.

Lovastatin

75330-75-5sc-200850
sc-200850A
sc-200850B
5 mg
25 mg
100 mg
$28.00
$88.00
$332.00
12
(1)

Primarily a cholesterol-lowering drug, Lovastatin can affect cell cycle progression. Its potential influence on Cdk2 is likely indirect, stemming from broader effects on cell cycle regulators.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Known to primarily target mTOR, Rapamycin has downstream effects on the cell cycle. By influencing mTOR and its associated pathways, Rapamycin might indirectly modulate Cdk2 activity.