Cdc42EP3 Inhibitors
Cdc42EP3 inhibitors are chemical compounds that directly or indirectly impact the function of Cdc42EP3, a protein involved in various signaling pathways. Compounds like Secramine A, ML141, AZA1, NSC 23766, ZCL278, Y16, CASIN, ITX3, EHop-016, Rhosin, MBQ-167, and CID-2950007 can lead to decreased functional activity of Cdc42EP3 through specific signaling pathways or biological processes that it is directly involved in.
Secramine A, ML141, AZA1, ZCL278, CASIN, EHop-016, and MBQ-167 are all inhibitors of Cdc42 GTPase. By inhibiting Cdc42, these compounds directly decrease the functional activity of Cdc42EP3, which is a known effector of Cdc42. In particular, Secramine A and ZCL278 work by disrupting the interaction between Cdc42 and its guanine nucleotide exchange factors (GEFs), inhibiting the activation of Cdc42. Similarly, ITX3 and CID-2950007 inhibit specific GEFs (Trio and GEF-H1 respectively), which are involved in the activation of Cdc42 and other Rho GTPases, thereby leading to decreased Cdc42EP3 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a potent, selective inhibitor of Cdc42 GTPase. It inhibits the activation of Cdc42, thereby leading to decreased Cdc42EP3 activity. | ||||||
AZA1 | 1071098-42-4 | sc-507497 | 10 mg | $600.00 | ||
AZA1 is a Rac1/Cdc42 GTPase inhibitor. By inhibiting Rac1/Cdc42, AZA1 can decrease the functional activity of Cdc42EP3. | ||||||
ZCL278 | 587841-73-4 | sc-507369 | 10 mg | $115.00 | ||
ZCL278 is a direct inhibitor of Cdc42 by targeting its binding with the GEF DOCK6. This can lead to decreased functional activity of Cdc42EP3. | ||||||
CASIN | 425399-05-9 | sc-397016 | 10 mg | $460.00 | 1 | |
CASIN is a selective inhibitor of Cdc42. It inhibits the activation of Cdc42, leading to decreased Cdc42EP3 activity. | ||||||
ITX 3 | 347323-96-0 | sc-295214 sc-295214A | 10 mg 50 mg | $145.00 $615.00 | ||
ITX3 is a specific inhibitor of Trio, a GEF for Cdc42. By inhibiting Trio, ITX3 can lead to decreased Cdc42EP3 activity. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
EHop-016 is an inhibitor of Rac1 and Cdc42. It inhibits the activation of these GTPases, leading to decreased Cdc42EP3 activity. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin is a selective inhibitor of RhoA GTPase. By inhibiting RhoA, it indirectly affects the balance of Rho GTPases, which can lead to decreased Cdc42EP3 activity. | ||||||