Cdc42EP3 Activators
Cdc42EP3 Activators are a diverse group of compounds that influence the protein's function through various mechanisms, primarily related to the modulation of intracellular cAMP levels, Rho GTPase signaling, and kinase activity. Cdc42EP3 is a scaffolding protein that interacts with effectors of the Rho family of GTPases, such as Rac1, to modulate their activity. Several of these compounds, such as EGF, LY294002, and Sphingosine-1-Phosphate, mediate their effects through these GTPases, leading to the activation of Cdc42EP3 and enhancement of its scaffolding functions.
Other Cdc42EP3 activators operate through cAMP-dependent signaling and kinase activation. For instance, Epinephrine, Forskolin, IBMX, Caffeine, Prostaglandin E2, and PACAP enhance intracellular levels of cAMP, which activates Protein Kinase A (PKA). PKA can then phosphorylate and activate Cdc42EP3, enhancing its ability to scaffold for effector proteins. Similarly, Bradykinin and Vasopressin operate through the IP3/DAG pathway, leading to Protein Kinase C (PKC) activation. Activated PKC can also phosphorylate and activate Cdc42EP3. LPA, on the other hand, functions through the Rho/Rho kinase pathway, with activated Rho kinase capable of phosphorylating and activating Cdc42EP3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates the β2-adrenergic receptor, which stimulates the cAMP/PKA pathway. PKA can phosphorylate and activate Cdc42EP3, enhancing its ability to scaffold for effector proteins. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 inhibits PI 3-kinase, which can lead to decreased Akt signaling and increased activity of its downstream effector Rac1. Activated Rac1 can bind to and activate Cdc42EP3. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular levels of cyclic AMP (cAMP). The rise in cAMP triggers the activation of Protein Kinase A (PKA). PKA can phosphorylate and activate Cdc42EP3. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, leading to an increase in intracellular cAMP levels. The elevated cAMP can activate PKA, which then phosphorylates and activates Cdc42EP3. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases leading to an increase in intracellular cAMP levels. The increased cAMP levels can activate PKA, which can phosphorylate and activate Cdc42EP3. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA activates the LPA receptor, which stimulates the Rho/Rho kinase pathway. Activated Rho kinase can phosphorylate and activate Cdc42EP3. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-Phosphate activates the S1P receptor, which can activate Rac1. Activated Rac1 can bind to and activate Cdc42EP3. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 activates the EP2 receptor, which stimulates the cAMP/PKA pathway. PKA can phosphorylate and activate Cdc42EP3. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates the B2 receptor, which stimulates the IP3/DAG pathway, leading to PKC activation. Activated PKC can phosphorylate and activate Cdc42EP3. | ||||||
Vasopressin | 11000-17-2 | sc-356188 sc-356188A | 5 mg 25 mg | $255.00 $1020.00 | 1 | |
Vasopressin activates the V1 receptor, which stimulates the IP3/DAG pathway, leading to PKC activation. Activated PKC can phosphorylate and activate Cdc42EP3. | ||||||