Cdc26 Inhibitors
The clCdc26 Inhibitors encompasses a diverse array of compounds that can act directly on the APC/C complex or influence its function in the broader context of cellular protein turnover. Among the primary approaches, we have compounds like Apcin and TAME that directly interfere with APC/C activation.
A different strategy lies in inhibiting the downstream effects of the APC/C, particularly the proteasomal degradation of target proteins. Compounds such as MG132, Bortezomib, ALLN, Lactacystin, Epoxomicin, and Celastrol fall under this category. By halting the proteasome, they disrupt the intended outcome of the APC/C-Cdc26 mediated ubiquitination, creating a backlog of ubiquitinated proteins and impacting the cell cycle's normal progression. Furthermore, compounds like MLN4924 shed light on another layer of complexity. By inhibiting the NEDD8-activating enzyme and thereby affecting Cullin-RING ligases, they highlight the interconnected nature of the ubiquitination pathway and the multiple nodes at which Cdc26's function can be influenced.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor, it prevents degradation of APC/C substrates, potentially influencing the activity of the APC/C-Cdc26 complex. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
As a proteasome inhibitor, it can indirectly influence Cdc26 by inhibiting proteasomal degradation. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
Inhibits the NEDD8-activating enzyme which can affect Cullin-RING ligases, potentially influencing processes related to APC/C-Cdc26 function. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Specific proteasome inhibitor, indirectly affecting the APC/C-Cdc26 mediated protein turnover. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Another proteasome inhibitor that can affect the degradation of APC/C targets and thereby impact Cdc26. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
It is a proteasome inhibitor and can affect cellular pathways in which Cdc26 is involved, indirectly influencing its function. | ||||||