CD67 Activators
Activators of the protein CD67, identified by its gene name CEACAM8, are a collection of chemical compounds that indirectly amplify its functional activity through distinct signaling pathways. Forskolin, by increasing intracellular cAMP levels, indirectly enhances CD67's role in cell-cell adhesion by facilitating the activation of PKA, which may phosphorylate proteins involved in adhesion, thereby promoting CD67-mediated functions. Epigallocatechin gallate, as a kinase inhibitor, indirectly bolsters CD67's activity by attenuating negative regulatory signals, allowing adhesion processes associated with CD67 to proceed with reduced interference. Sphingosine-1-phosphate, through its lipid signaling modulation, and Thapsigargin, by elevating intracellular calcium, both contribute to the cellular environment that favors CD67 activity in adhesion. PMA, acting as a PKC activator, and the PI3K inhibitors LY294002 and Wortmannin, alter signaling dynamics in a way that can lead to an enhancement of CD67-related adhesion processes.
The activity of CD67 is further influenced by compounds affecting the MAPK signaling cascade. U0126 and SB203580, as specific inhibitors of MEK1/2 and p38 MAP kinase, respectively, may indirectly lead to the enhancement of CD67 by shifting signaling equilibrium towards pathways that CD67 is involved in. Genistein, a tyrosine kinase inhibitor, could enhance CD67 activity by reducing competitive tyrosine kinase signaling, which often acts as a negative regulator in adhesion pathways. Staurosporine, despite its broad kinase inhibition, might result in the selective activation of CD67 pathways by diminishing the inhibitory effects exerted by specific kinases on CD67-associated processes. A23187, by increasing intracellular calcium, supports signaling pathways crucial for cell-cell adhesion, potentially augmenting the function of CD67 in these processes. Collectively, these activators, through their targeted biochemical actions, serve to enhance the functional activity of CD67 by influencing the signaling pathways and cellular processes that are foundational to its role.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpenoid that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate specific substrates that may include those associated with CEACAM8, thereby enhancing its functional activity connected to cellular adhesion processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This polyphenol acts as an antioxidant and has been shown to inhibit several protein kinases. By inhibiting these kinases, it may indirectly enhance the activity of CEACAM8 by reducing negative regulatory influences on the protein’s associated adhesion pathways. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) is a lipid signaling molecule that binds to its specific G-protein-coupled receptors, leading to downstream activation of pathways, including those that govern cytoskeletal rearrangements and cellular adhesion. This could enhance the adhesive functions of CEACAM8 by promoting the cellular context that favors its activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. By inhibiting p38 MAP kinase, it may result in the enhancement of other signaling pathways or proteins, potentially including CEACAM8, as cellular signaling systems often compensate for the inhibition of one pathway by upregulating others. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). Elevated intracellular calcium can activate numerous calcium-dependent signaling pathways, which may indirectly enhance the activity of CEACAM8 by promoting adhesion-related signaling processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and acts as a potent activator of protein kinase C (PKC). Activation of PKC leads to phosphorylation of target proteins and modulation of signaling pathways associated with cellular adhesion, which could enhance the functional activity of CEACAM8 in adhesion-related processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a steroidal metabolite that acts as an irreversible inhibitor of PI3K. By inhibiting PI3K, Wortmannin could indirectly enhance the activity of CEACAM8 by shifting cellular signaling dynamics towards pathways that promote the protein's function in cellular adhesion. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that functions as a tyrosine kinase inhibitor. By inhibiting certain tyrosine kinases, it may reduce competitive signaling and thereby enhance pathways that upregulate the functional activity of CEACAM8, especially in pathways related to cell-cell adhesion. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent non-selective inhibitor of protein kinases. Despite its broad-spectrum inhibition, it might lead to the selective enhancement of CEACAM8 pathways by reducing the activity of kinases that negatively regulate pathways associated with CEACAM8's function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that selectively increases intracellular calcium levels. Elevated calcium can activate various calcium-dependent signaling pathways, potentially enhancing the functional activity of CEACAM8 through the promotion of pathways that support its role in cell adhesion and signaling. | ||||||