CD48 Activators
CD48 Activators are chemical compounds that interact with CD48 or the pathways it is directly involved in, enhancing the functional activity of CD48. Phorbol 12-myristate 13-acetate and Lipopolysaccharide enhance CD48 activity by activating the NF-κB pathway, in which CD48 is involved. Resveratrol enhances the activity of CD48 by activating Sirtuin 1, leading to deacetylation of NF-κB, thereby enhancing its activity. Epigallocatechin gallate and Curcumin can enhance the functional activity of CD48 by inhibiting the activity of DNA methyltransferases, leading to hypomethylation of the CD48 promoter and increased gene activity. Sodium butyrate enhances the activity of CD48 by inhibitinghistone deacetylase, leading to hyperacetylation of histones at the CD48 promoter and consequently increased gene activity.
BAY 11-7082 and Parthenolide are inhibitors of IκBα phosphorylation, leading to activation of NF-κB, which is a pathway that CD48 is involved in. This activation, therefore, can enhance the functional activity of CD48. Anacardic acid, on the other hand, inhibits histone acetyltransferases, which may result in hypoacetylation of histones at the CD48 promoter, leading to increased gene activity and enhanced functional activity of CD48. Genistein and Quercetin inhibit the activity of DNA methyltransferases, which can lead to hypomethylation of the CD48 promoter, leading to increased gene activity and enhanced functional activity of CD48. Lastly, Caffeic acid phenethyl ester inhibits NF-κB activation by preventing the degradation of IκBα, which can lead to enhanced functional activity of CD48, as it is involved in the NF-κB pathway.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC) which, in turn, activates the NF-κB pathway. CD48 is known to be involved in the NF-κB pathway, and thus activation of this pathway can enhance the functional activity of CD48. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS is a potent activator of Toll-like receptor 4 (TLR4). TLR4 signaling activates the NF-κB pathway, which CD48 is involved in, thus leading to enhanced functional activity of CD48. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate Sirtuin 1 (SIRT1). SIRT1 activation can lead to deacetylation of NF-κB, enhancing its activity. As CD48 is involved in the NF-κB pathway, the enhanced activity of NF-κB can lead to increased functional activity of CD48. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG can inhibit the activity of DNA methyltransferases (DNMTs). Inhibition of DNMTs may result in hypomethylation of the CD48 promoter, leading to increased gene activity and consequently enhanced functional activity of CD48. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase (HDAC) inhibitor. Inhibition of HDACs can lead to hyperacetylation of histones at the CD48 promoter, leading to enhanced gene activity and consequently enhanced functional activity of CD48. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an inhibitor of IκBα phosphorylation which leads to activation of NF-κB. As CD48 is involved in the NF-κB pathway, the activation of NF-κB can enhance the functional activity of CD48. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit the activity of DNMTs. This may lead to hypomethylation of the CD48 promoter, leading to increased gene activity and enhanced functional activity of CD48. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid is a known inhibitor of histone acetyltransferases (HATs). Inhibition of HATs may result in hypoacetylation of histones at the CD48 promoter, leading to increased gene activity and enhanced functional activity of CD48. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide is an inhibitor of IκBα phosphorylation, which leads to activation of NF-κB. As CD48 is involved in the NF-κB pathway, the activation of NF-κB can lead to enhanced functional activity of CD48. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor which can inhibit the activity of DNMTs. This can lead to hypomethylation of the CD48 promoter, leading to increased gene activity and enhanced functional activity of CD48. | ||||||