CD39L3 Activators
CD39L3 Activators are a chemical class that modulates the protein CD39L3, involved in extracellular ATP hydrolysis and purinergic signaling. The compounds in this selection primarily act by influencing cAMP levels, a key regulator of CD39L3 expression and activity. Forskolin, IBMX, Rolipram, BAY 60-6583, NECA, and 8-Br-cAMP all serve to increase intracellular cAMP levels. Forskolin achieves this by directly stimulating adenylyl cyclase, the enzyme responsible for cAMP production. IBMX and Rolipram, on the other hand, inhibit phosphodiesterases, blocking cAMP breakdown. BAY 60-6583 and NECA activate adenosine receptors, which can also lead to heightened cAMP levels. 8-Br-cAMP, a cell-permeable cAMP analog, raises intracellular cAMP levels directly.
On the other side, H89, SQ22536, MDL-12330A, ZM241385, SCH58261, and DPCPX can modulate cAMP signaling in a way that indirectly influences CD39L3. H89 inhibits PKA, a downstream effector ofcAMP, affecting the subsequent signaling cascade. SQ22536 and MDL-12330A inhibit adenylyl cyclase, reducing cAMP production and potentially altering CD39L3 activity. ZM241385, SCH58261, and DPCPX are antagonists of different adenosine receptors, blocking the receptor-mediated increase in cAMP levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP levels can enhance the activity of CD39L3 by upregulating its expression and activity, as CD39L3 has been shown to be regulated by cAMP signaling. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By inhibiting these enzymes, IBMX raises intracellular cAMP levels, which can lead to upregulation of CD39L3 expression and activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), which breaks down cAMP. By inhibiting PDE4, Rolipram increases cAMP levels, thereby enhancing CD39L3 activity by upregulating its expression. | ||||||
BAY 60-6583 | 910487-58-0 | sc-503262 | 10 mg | $210.00 | ||
BAY 60-6583 is a selective A2B adenosine receptor agonist. Activation of the A2B receptor can increase intracellular cAMP levels, which in turn can enhance CD39L3 activity through upregulation of its expression and activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP is a cell-permeable cAMP analog. By increasing intracellular cAMP levels, 8-Br-cAMP can enhance the activity of CD39L3 by upregulating its expression. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H89 is a potent inhibitor of protein kinase A (PKA), which is activated by cAMP. By inhibiting PKA, H89 can influence the downstream effects of cAMP signaling, potentially upregulating CD39L3 expression and activity. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $95.00 $363.00 | 13 | |
SQ22536 is an adenylyl cyclase inhibitor. By inhibiting adenylyl cyclase, SQ22536 can modulate cAMP levels and thus affect CD39L3 expression and activity. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
MDL-12330A is an adenylyl cyclase inhibitor. It can modulate cAMP levels, potentially affecting the expression and activity of CD39L3. | ||||||
ZM 241385 | 139180-30-6 | sc-361421 sc-361421A | 5 mg 25 mg | $92.00 $356.00 | 1 | |
ZM241385 is a potent antagonist of the A2A adenosine receptor. By blocking the A2A receptor, ZM241385 can modulate cAMP levels, influencing the expression and activity of CD39L3. | ||||||
SCH 58261 | 160098-96-4 | sc-204272 sc-204272A | 10 mg 50 mg | $195.00 $825.00 | ||
SCH58261 is a potent and selective antagonist of the A2A adenosine receptor, thus it can modulate cAMP levels and potentially affect the expression and activity of CD39L3. | ||||||