Date published: 2026-5-3

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CD37 Inhibitors

CD37 inhibitors belong to a class of chemical compounds that target the CD37 protein, a transmembrane glycoprotein belonging to the tetraspanin family. The CD37 protein is primarily expressed on the surface of B cells, playing a crucial role in various cellular processes, including cell adhesion, signal transduction, and immune response modulation. As a member of the tetraspanin superfamily, CD37 is involved in forming molecular complexes with other cell surface proteins, contributing to the regulation of B cell activation and function. CD37 inhibitors are meticulously designed molecules that interact specifically with the CD37 protein, disrupting its normal function or altering its interactions with other proteins. The development of these inhibitors involves a deep understanding of the structural and biochemical characteristics of CD37, enabling the design of compounds that can selectively bind to the protein and modulate its activity. By influencing the function of CD37, these inhibitors have the potential to impact various aspects of B cell biology, making them valuable tools for researchers exploring the intricate mechanisms governing immune responses. The ongoing exploration of CD37 inhibitors contributes to our broader understanding of immune system regulation and may open new avenues for the development of novel approaches to modulate immune responses in health and disease.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Wortmannin is a steroidal metabolite of fungi that acts as a potent and irreversible inhibitor of phosphoinositide 3-kinases (PI3K), which can influence signaling cascades that may be modulated by CD37.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

LY294002 is a synthetic molecule functioning as a PI3K inhibitor, impacting various cellular processes that could be downstream of CD37 activity.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$70.00
$145.00
51
(1)

Dasatinib is a synthetic compound designed as a tyrosine kinase inhibitor, affecting signal transduction pathways that might intersect with CD37's regulatory networks.

Ibrutinib

936563-96-1sc-483194
10 mg
$156.00
5
(0)

Ibrutinib is a small molecule that inhibits Bruton's tyrosine kinase (BTK), potentially affecting B cell activity and signaling involving CD37.

CAL-101

870281-82-6sc-364453
10 mg
$193.00
4
(1)

Idelalisib is a selective PI3K inhibitor, targeting specifically the delta isoform, which is implicated in the activity of B cells where CD37 is present.

ABT-199

1257044-40-8sc-472284
sc-472284A
sc-472284B
sc-472284C
sc-472284D
1 mg
5 mg
10 mg
100 mg
3 g
$118.00
$337.00
$520.00
$832.00
$1632.00
10
(0)

Venetoclax is a BCL-2 inhibitor, which indirectly influences survival pathways in B cells expressing CD37.

Palbociclib

571190-30-2sc-507366
50 mg
$321.00
(0)

Palbociclib is an inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), which could indirectly affect cell cycle progression in cells interacting with CD37.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin inhibits mTOR, a key kinase in regulating cell growth and proliferation, potentially intersecting with CD37 signaling.

MLN8237

1028486-01-2sc-394162
5 mg
$220.00
(0)

Alisertib is an Aurora kinase A inhibitor, which can influence cell cycle and proliferation, affecting the cellular context of CD37.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Bortezomib is a proteasome inhibitor, affecting protein degradation pathways that might be connected to CD37's function.