CD1A Activators
CD1A is a member of the CD1 family of transmembrane glycoproteins, primarily expressed on the surface of antigen-presenting cells (APCs) such as dendritic cells, monocytes, and Langerhans cells. Unlike classical major histocompatibility complex (MHC) molecules, which present peptide antigens to T cells, CD1 proteins are specialized in presenting lipid and glycolipid antigens to T cells, particularly to subsets of T cells known as lipid-reactive T cells. The function of CD1A is pivotal in the immune system's recognition and response to lipid antigens from pathogens such as bacteria, fungi, and mycobacteria, as well as endogenous lipid antigens involved in self-recognition and immune regulation.
Activation of CD1A involves a series of intricate processes that culminate in the loading and presentation of lipid antigens to T cells. In antigen-presenting cells, newly synthesized CD1A molecules are trafficked through the endocytic pathway, where they encounter endogenous lipids or lipid antigens acquired from the extracellular environment. These lipid antigens are then internalized into intracellular compartments, such as endosomes or lysosomes, where they are processed and loaded onto CD1A molecules. This process is facilitated by various lipid-binding proteins and lipid transfer proteins within the endocytic pathway. Once loaded with lipid antigens, CD1A molecules are transported to the cell surface, where they interact with lipid-reactive T cells, leading to T cell activation and initiation of immune responses against the presenting antigen. Overall, the activation of CD1A plays a crucial role in mediating immune recognition and response to lipid antigens, contributing to the immune system's ability to combat pathogens and maintain immune homeostasis.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
Imiquimod is a toll-like receptor 7 (TLR7) agonist that directly activates CD1A. By binding to TLR7, imiquimod induces a signaling cascade that leads to the upregulation of CD1A expression. This direct activation highlights the role of TLR7-mediated pathways in regulating CD1A and suggests a potential avenue for modulating CD1A activity in immune responses. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
R-848 is a toll-like receptor 7 (TLR7) and TLR8 agonist that directly activates CD1A. Through the activation of TLR7 and TLR8, resiquimod triggers intracellular signaling pathways that result in the upregulation of CD1A expression. | ||||||
Pam3Cys-Ser-(Lys)4, Hydrochloride | 112208-00-1 | sc-507471 | 2 mg | $550.00 | ||
Pam3CSK4 is a synthetic lipopeptide that directly activates CD1A by engaging toll-like receptor 2 (TLR2). Through TLR2 activation, Pam3CSK4 initiates intracellular signaling cascades leading to the upregulation of CD1A expression. This direct modulation emphasizes the specific role of TLR2-mediated pathways in CD1A regulation and suggests a connection between bacterial lipopeptides and the activation of CD1A in the context of immune responses. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Lipopolysaccharide (LPS) is a toll-like receptor 4 (TLR4) agonist that directly activates CD1A. Through TLR4 engagement, LPS triggers intracellular signaling cascades leading to the upregulation of CD1A expression. This direct activation emphasizes the involvement of TLR4-mediated pathways in CD1A regulation, providing insights into the potential connection between bacterial endotoxins and the activation of CD1A in the context of immune responses. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that indirectly activates CD1A. By modulating retinoic acid receptors (RARs), retinoic acid influences gene expression, including the upregulation of CD1A. This indirect activation highlights the role of retinoic acid signaling in regulating CD1A expression and suggests a potential link between vitamin A metabolism and the modulation of CD1A in immune responses. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
Calcitriol is the active form of vitamin D that indirectly activates CD1A. By binding to the vitamin D receptor (VDR), it modulates gene expression, including the upregulation of CD1A. This indirect activation underscores the connection between vitamin D signaling and the regulation of CD1A, providing insights into the potential influence of vitamin D on the expression and function of CD1A in immune responses. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Poly I:C is a synthetic double-stranded RNA that directly activates CD1A by engaging toll-like receptor 3 (TLR3). Through TLR3 activation, Poly I:C initiates intracellular signaling cascades leading to the upregulation of CD1A expression. This direct modulation highlights the specific role of TLR3-mediated pathways in CD1A regulation and suggests a potential link between viral mimicry and the activation of CD1A in the context of immune responses. | ||||||
Zymosan A from Saccharomyces cerevisiae | 58856-93-2 | sc-258367 sc-258367A | 250 mg 1 g | $90.00 $222.00 | 2 | |
Zymosan is a yeast cell wall extract that directly activates CD1A by engaging toll-like receptor 2 (TLR2). Through TLR2 activation, zymosan triggers intracellular signaling cascades leading to the upregulation of CD1A expression. This direct modulation emphasizes the role of TLR2-mediated pathways in CD1A regulation and suggests a potential connection between fungal components and the activation of CD1A in the context of immune responses. | ||||||
Oligomycin A | 579-13-5 | sc-201551 sc-201551A sc-201551B sc-201551C sc-201551D | 5 mg 25 mg 100 mg 500 mg 1 g | $179.00 $612.00 $1203.00 $5202.00 $9364.00 | 26 | |
Oligomycin A is an ATP synthase inhibitor that indirectly activates CD1A. By disrupting cellular ATP levels, oligomycin A influences gene expression, including the upregulation of CD1A. This indirect activation highlights the connection between cellular energy status and the regulation of CD1A, providing insights into the potential impact of ATP synthase inhibitors on the expression and function of CD1A in immune responses. | ||||||