Date published: 2026-4-24

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CD14 Inhibitors

CD14 is a glycoprotein primarily expressed on the surface of macrophages and monocytes, as well as certain dendritic cells. It plays a pivotal role in the innate immune system, functioning as a pattern recognition receptor (PRR) that recognizes pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) from Gram-negative bacteria. The primary function of CD14 is to facilitate the recognition and binding of these microbial molecules, thereby initiating immune responses against invading pathogens. Upon binding to PAMPs, CD14 activates downstream signaling pathways that lead to the production of pro-inflammatory cytokines and chemokines, as well as the upregulation of co-stimulatory molecules, ultimately promoting the clearance of pathogens and the initiation of adaptive immune responses. Inhibition of CD14 can be achieved through various mechanisms, all of which aim to disrupt its interaction with PAMPs and subsequent activation of immune responses. One approach to inhibiting CD14 function is through the use of competitive inhibitors that block the binding site of CD14, preventing its interaction with PAMPs. Another strategy involves interfering with downstream signaling pathways activated by CD14, thereby inhibiting the production of inflammatory mediators. Additionally, modulating the expression or activity of CD14 itself can also be employed as a means of inhibition. By targeting CD14, it is possible to attenuate excessive immune responses and inflammation associated with various infectious and inflammatory diseases.

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rosiglitazone

122320-73-4sc-202795
sc-202795A
sc-202795C
sc-202795D
sc-202795B
25 mg
100 mg
500 mg
1 g
5 g
$120.00
$326.00
$634.00
$947.00
$1259.00
38
(1)

Rosiglitazone, a PPARγ agonist, has been shown to reduce CD14 expression in monocytes. It may exert its effect by modulating the transcriptional activity of genes associated with inflammation and immune responses.

Lovastatin

75330-75-5sc-200850
sc-200850A
sc-200850B
5 mg
25 mg
100 mg
$29.00
$90.00
$339.00
12
(1)

Lovastatin, a member of the statin class, not only lowers cholesterol but also modulates immune responses. It has been reported to reduce CD14 expression, potentially by inhibiting the prenylation of proteins involved in its expression pathway.

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

Dexamethasone is a potent glucocorticoid that possesses anti-inflammatory properties. It can reduce CD14 expression on monocytes, possibly by interfering with transcriptional factors or signaling pathways that regulate CD14 gene expression.

Sulindac

38194-50-2sc-202823
sc-202823A
sc-202823B
1 g
5 g
10 g
$32.00
$86.00
$150.00
3
(1)

Sulindac has shown potential in reducing CD14 expression. It may exert its effect by inhibiting cyclooxygenase pathways, leading to a decrease in inflammatory mediators that stimulate CD14 expression.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin, a bioactive compound from turmeric, exhibits anti-inflammatory properties. It has been suggested to reduce CD14 expression by modulating NF-κB signaling, a key pathway in regulating CD14 expression.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin is a flavonoid with antioxidant and anti-inflammatory activities. It might reduce CD14 expression by inhibiting pathways associated with inflammation and oxidative stress, which can up-regulate CD14.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol, a polyphenol found in grapes, has anti-inflammatory properties. It can potentially suppress CD14 expression by modulating signaling pathways like NF-κB and MAPK, which regulate CD14 expression.

Emodin

518-82-1sc-202601
sc-202601A
sc-202601B
50 mg
250 mg
15 g
$105.00
$214.00
$6255.00
2
(1)

Emodin, an anthraquinone derivative, exhibits anti-inflammatory properties. It might decrease CD14 expression by inhibiting the NF-κB pathway, which is crucial for CD14 gene transcription.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

Epigallocatechin gallate (EGCG), a major component of green tea, has anti-inflammatory effects. It can potentially down-regulate CD14 expression by inhibiting various signaling pathways associated with inflammation and immune responses.

Luteolin

491-70-3sc-203119
sc-203119A
sc-203119B
sc-203119C
sc-203119D
5 mg
50 mg
500 mg
5 g
500 g
$27.00
$51.00
$101.00
$153.00
$1925.00
40
(1)

Luteolin is a flavonoid with antioxidant and anti-inflammatory activities. It may suppress CD14 expression by inhibiting the activation of transcription factors and signaling pathways that up-regulate CD14 in response to inflammatory stimuli.