CCDC60_Ccdc60 Activators
CCDC60 play a pivotal role in modulating its function by various mechanisms that ultimately lead to an increase in cyclic AMP (cAMP) levels within the cell. Forskolin, by directly activating adenylyl cyclase, prompts a surge in cAMP, which then activates protein kinase A (PKA). Activated PKA can phosphorylate CCDC60, which is integral to its role in ciliary movement and structure. Similarly, Isoproterenol, functioning as a beta-adrenergic agonist, and Epinephrine, through binding to beta-adrenergic receptors, initiate adenylyl cyclase activity, thereby raising cAMP concentrations and activating PKA, which in turn may phosphorylate CCDC60. Dopamine, engaging with D1-like receptors and Histamine, interacting with H2 receptors, both facilitate an increase in cAMP via their respective pathways, culminating in the activation of PKA and subsequent phosphorylation of CCDC60.
IBMX and Rolipram, obstruct the breakdown of cAMP by inhibiting phosphodiesterases, thus indirectly fostering an environment conducive to PKA activation and CCDC60 phosphorylation. Cholera toxin, by irreversibly activating the Gs alpha protein, elicits a persistent increase in cAMP, leading to a prolonged PKA activation. Anagrelide, with its specificity for cAMP phosphodiesterase III, and Terbutaline, a beta2-adrenergic agonist, also contribute to the elevation of cAMP and consequent PKA-mediated phosphorylation of CCDC60. Salbutamol, another beta2-adrenergic agonist, similarly stimulates adenylyl cyclase, leading to increased cAMP and PKA activity. Prostaglandin E2 (PGE2) invokes G protein-coupled receptors that yield higher cAMP levels, paving the way for PKA activation. All these activators, through their distinct interactions, facilitate the activation of CCDC60, which is essential for the proper functioning of ciliary structures.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing levels of cyclic AMP (cAMP) within cells. As CCDC60 is speculated to be involved in ciliary function and structure, increased cAMP may stimulate protein kinase A (PKA), which can then phosphorylate substrates associated with ciliary movement, potentially enhancing CCDC60 activity as part of the ciliary structure. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that stimulates adenylyl cyclase via G protein-coupled receptor signaling, leading to increased cAMP production. Elevated cAMP activates PKA, which may phosphorylate and activate proteins within the ciliary apparatus, potentially including CCDC60, thus enhancing its function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases (PDEs), enzymes that break down cAMP. By preventing cAMP degradation, IBMX indirectly increases cAMP levels, which could activate PKA and subsequently lead to the phosphorylation and functional activation of CCDC60 in ciliary processes. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) activates G protein-coupled receptors that can increase intracellular cAMP. This rise in cAMP could activate PKA, which may phosphorylate and activate CCDC60, thereby potentially enhancing its role in ciliary function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram selectively inhibits PDE4, which degrades cAMP. Inhibition of PDE4 increases cAMP levels, leading to PKA activation. PKA may then activate CCDC60 through phosphorylation, enhancing its functional role in cilia. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to beta-adrenergic receptors, leading to the activation of adenylyl cyclase and increased cAMP production. The subsequent activation of PKA might lead to phosphorylation and activation of CCDC60 as part of the signaling cascade associated with ciliary motion. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to its G protein-coupled receptors, particularly the D1-like receptors that increase cAMP levels. As cAMP rises, PKA is activated, which could then phosphorylate and activate CCDC60, potentially enhancing ciliary function. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine, through its H2 receptors, can increase cAMP levels by activating adenylyl cyclase. The increase in cAMP may activate PKA, which could lead to phosphorylation and functional activation of CCDC60 in ciliary structures. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide is a phosphodiesterase inhibitor with a higher specificity for cAMP phosphodiesterase III. By inhibiting this enzyme, it increases cAMP levels, which could lead to PKA activation and subsequent phosphorylation and activation of the CCDC60 protein. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline, a beta2-adrenergic agonist, activates adenylyl cyclase through its receptor, leading to increased cAMP. The elevated cAMP activates PKA, which may lead to phosphorylation and activation of CCDC60, potentially affecting ciliary function. | ||||||