CCDC55 Inhibitors
CCDC55 inhibits the proteasome with a compound like MG-132, the degradation of cellular proteins is affected, which could lead to a non-specific accumulation of proteins including CCDC55, potentially overwhelming the protein folding machinery and leading to a reduction in functional CCDC55 levels. Similarly, compounds like Cycloheximide and Brefeldin A disrupt protein synthesis and transport, respectively, which can have a downstream effect on the levels and localization of CCDC55.
Chemicals such as Staurosporine and the Hsp90 inhibitors 17-AAG and Geldanamycin impact cellular signaling and protein folding. While Staurosporine is a broad-spectrum kinase inhibitor that could influence phosphorylation-dependent signaling pathways related to CCDC55, 17-AAG and Geldanamycin specifically destabilize proteins dependent on Hsp90, which may include CCDC55 if it is an Hsp90 client protein. Chloroquine and U18666A affect lysosomal degradation and cholesterol trafficking, respectively, with potential impacts on membrane-bound or membrane-associated proteins like CCDC55. Lipid raft-disrupting agents like Filipin III could alter the localization or function of CCDC55 if it associates with cholesterol-rich membrane domains.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can prevent the degradation of various proteins, potentially increasing competition for cellular machinery that processes proteins like CCDC55. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibitor of eukaryotic protein synthesis by interfering with the translocation step in protein synthesis, possibly decreasing overall protein levels including CCDC55. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that can nonspecifically inhibit many kinases, which may indirectly affect phosphorylation states of proteins like CCDC55. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Inhibitor of protein transport from the endoplasmic reticulum to the Golgi apparatus, potentially affecting the processing and trafficking of proteins like CCDC55. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Lysosomotropic agent that can increase the pH in lysosomes, potentially affecting the degradation of cellular components including misfolded or damaged CCDC55 proteins. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $143.00 $510.00 | 2 | |
Cholesterol transport inhibitor that can disrupt intracellular cholesterol distribution and potentially affect the membrane-associated functions or localizations of proteins like CCDC55. | ||||||
Filipin III | 480-49-9 | sc-205323 sc-205323A | 500 µg 1 mg | $118.00 $148.00 | 26 | |
Binds to cholesterol, disrupting lipid rafts in cellular membranes and potentially altering the localization or function of membrane-associated proteins like CCDC55. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
Hsp90 inhibitor which can destabilize client proteins, potentially affecting the stability and function of proteins like CCDC55 that rely on Hsp90 for proper folding. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Another Hsp90 inhibitor, similar in function to 17-AAG, which may compromise the stability of proteins like CCDC55. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Microtubule-disrupting agent that can affect cell division and trafficking pathways, potentially impacting the distribution or function of proteins like CCDC55 within cells. | ||||||