CCDC3 Inhibitors
Chemical inhibitors of CCDC3 can significantly affect the protein's activity by disrupting the signaling pathways on which it relies. Chelerythrine and GF109203X, both protein kinase C (PKC) inhibitors, can impede the signaling necessary for CCDC3 function, as PKC is involved in cell differentiation and response to extracellular signals. Similarly, the pan-PKC inhibitor Gö 6983 can disrupt various PKC isoforms, possibly affecting the CCDC3 activity that depends on these signaling cascades. On another front, LY294002 and Wortmannin target the PI3K/AKT pathway, where their inhibition of PI3K can prevent AKT activation, leading to a reduction in cell survival signals that can be vital for CCDC3's role. Rapamycin, an mTOR inhibitor, can also inhibit downstream effects in the PI3K/AKT pathway, potentially impeding processes essential for CCDC3 activity.
Further, PD 98059 and U0126, which specifically inhibit MEK1/2 in the MAPK/ERK pathway, can prevent the activation of ERK, which is crucial for cell proliferation and differentiation functions associated with CCDC3. SB203580 and SP600125, which selectively inhibit p38 MAP kinase and JNK respectively, can interfere with CCDC3-related functions by disrupting the cellular response to stress stimuli and the regulation of apoptosis and cellular proliferation. Y-27632, a selective inhibitor of ROCK kinases, can impede the organization of the actin cytoskeleton, a process that can be critical for CCDC3's activity. Lastly, PP2, a selective inhibitor of Src family kinases, can interfere with multiple signaling pathways, including those related to cell proliferation and differentiation, potentially altering the proper function of CCDC3. Through these various mechanisms, the selected chemical inhibitors can exert a significant influence on the functional expression of CCDC3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent inhibitor of protein kinase C (PKC), which is involved in multiple signaling pathways, including those regulating cell differentiation and response to extracellular signals. Inhibition of PKC can disrupt the signaling necessary for CCDC3 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 specifically inhibits MEK, which is upstream of MAPK/ERK. The MAPK/ERK pathway is involved in the regulation of a variety of cellular processes, including proliferation. Inhibition of MEK consequently inhibits ERK activation, potentially affecting CCDC3 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K, which plays a critical role in the AKT signaling pathway. PI3K inhibition can prevent the activation of AKT, leading to a reduction in cell survival signals that may be necessary for proper CCDC3 functionality. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. The p38 MAPK pathway is implicated in the response to stress stimuli and is involved in cell cycle regulation. Inhibiting this pathway can interfere with cellular functions that are potentially necessary for CCDC3 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK, which is part of the MAPK signaling pathways. JNK pathway is associated with the regulation of apoptosis and cellular proliferation. Inhibition of JNK signaling can interrupt processes that might be crucial for the functional expression of CCDC3. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are kinases in the MAPK/ERK pathway. By inhibiting MEK1/2, U0126 prevents the activation of ERK, which could disrupt signaling necessary for CCDC3's role in cell proliferation and differentiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. By inhibiting PI3K, it prevents the phosphorylation and activation of AKT, potentially impeding the survival and proliferation pathways that are necessary for CCDC3 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor, and mTOR is a key component of the PI3K/AKT pathway, which is involved in cell survival, proliferation, and growth. Inhibition of mTOR by rapamycin could inhibit downstream effects that are necessary for the functional activity of CCDC3. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X is an inhibitor of protein kinase C (PKC). Since PKC is involved in various cellular functions including cell growth and differentiation, inhibiting PKC with GF109203X may impede signaling pathways on which CCDC3 relies for proper function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK kinases. The Rho/ROCK pathway is involved in actin cytoskeleton organization, which is critical for various cellular processes. Inhibition of ROCK may impede cellular mechanisms that are necessary for the activity of CCDC3. | ||||||