CCDC164 Inhibitors

Staurosporine is a general kinase inhibitor known for its broad-spectrum activity against protein kinases which play pivotal roles in signaling pathways that regulate cell division, survival, and apoptosis. Inhibition of these kinases can lead to altered protein function and signal transduction. LY294002 and wortmannin are both inhibitors of PI3K, a lipid kinase involved in the PI3K/AKT/mTOR pathway, which is central in regulating cell growth and survival. Inhibition of this pathway can result in reduced protein synthesis and cell proliferation. Similarly, the inhibition of MEK by compounds like U0126 and PD98059 leads to the disruption of the MAPK/ERK pathway, which is another critical route for controlling cell cycle progression and differentiation.

Compounds like rapamycin, which target mTOR, can suppress cell growth and proliferation by affecting the downstream targets of mTOR. Cyclopamine acts on the Hedgehog pathway, which is important for cell differentiation and can influence the activity of various transcription factors. SB431542, by inhibiting the TGF-beta receptor, can modulate numerous cellular processes including cell proliferation and apoptosis. JNK pathway, which is associated with inflammatory responses and apoptosis, can be influenced by SP600125. Proteasome inhibitors like bortezomib disrupt the degradation of proteins, which is essential for cell cycle progression and the regulation of protein levels within the cell. ZM447439 and Y-27632 target enzymes such as Aurora kinases and ROCK kinase, respectively, affecting processes like mitosis and cell motility.