CCDC151 Inhibitors
CCDC151 Inhibitors are essentially compounds that affect the ciliogenesis pathway, in which CCDC151 plays a crucial role. Rapamycin, a well-known mTOR inhibitor, suppresses mTORC1 signaling thereby hindering protein synthesis and cellular growth processes that are essential for ciliogenesis. Since CCDC151 is implicated in ciliogenesis, the presence of Rapamycin leads to decreased functional activity of CCDC151 through its action on mTORC1. Other inhibitors, such as LY294002 and Wortmannin, target PI3K, a kinase upstream of mTOR signaling. Inhibition of PI3K consequently leads to reduced AKT phosphorylation and mTOR activity, implicating a decrease in CCDC151 activity due to the impaired ciliogenesis pathway.
Moreover, compounds like Torin 1, AZD8055, and PP242, which are selective mTOR inhibitors, exert a similar influence on ciliogenesis and, consequently, on CCDC151 activity. The effectiveness of these inhibitors stems from their ability to disrupt the mTOR signaling pathway, thereby affecting the assembly and maintenance of cilia, processes in which CCDC151 is presumed to be involved.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that suppresses mTORC1 signaling, leading to the inhibition of protein synthesis and cell growth, which are pivotal for ciliogenesis. Since CCDC151 is involved in ciliogenesis, the inhibition of mTORC1 by Rapamycin would result in decreased functional activity of CCDC151. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that blocks the PI3K/AKT/mTOR pathway, pivotal for numerous cellular processes. By inhibiting PI3K, LY294002 could reduce AKT phosphorylation and subsequent mTORC1 activity, thereby affecting ciliogenesis and consequentially inhibiting CCDC151 activity. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Autophagy inhibitor targeting PI3K, which diminishes autophagic flux. Since autophagy can be linked to ciliogenesis and CCDC151 is involved in ciliogenesis, 3-Methyladenine's inhibition of PI3K can indirectly decrease CCDC151 activity. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
A selective mTORC1/mTORC2 inhibitor that can disrupt the mTOR signaling pathway. By inhibiting both complexes of mTOR, it would attenuate ciliogenesis and indirectly inhibit CCDC151 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor, similar to LY294002, but irreversible. Wortmannin's inhibition of PI3K would lead to a downregulation of the PI3K/AKT/mTOR pathway, affecting ciliogenesis and indirectly reducing CCDC151 function. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $188.00 $327.00 | 1 | |
An alkylphospholipid that inhibits AKT activation. With AKT being a key component in the PI3K/AKT/mTOR pathway, Perifosine would disrupt downstream signaling affecting ciliogenesis, thereby indirectly inhibiting CCDC151 activity. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
An AKT inhibitor that prevents AKT phosphorylation and activation, thereby affecting downstream signaling including the mTOR pathway. This would indirectly inhibit CCDC151 by impairing ciliogenesis. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
A dual mTORC1/mTORC2 inhibitor that would hinder mTOR signaling, thus affecting ciliogenesis and indirectly leading to the inhibition of CCDC151 activity. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
A selective inhibitor of mTORC1 and mTORC2, which would disrupt ciliogenesis-related signaling, indirectly leading to CCDC151 inhibition. | ||||||
ZSTK 474 | 475110-96-4 | sc-475495 | 5 mg | $75.00 | ||
A PI3K inhibitor that by reducing the activity of the PI3K/AKT/mTOR pathway, would indirectly inhibit CCDC151 by affecting ciliogenesis. | ||||||