CCDC147 Inhibitors
CCDC147 inhibitors encompass a specialized group of chemical compounds designed to selectively interfere with the function of the CCDC147 protein, a protein encoded by the CCDC147 gene. These inhibitors operate by impeding the specific biological pathways in which CCDC147 is implicated, resulting in the attenuation of its activity. CCDC147 is known to play a role in cellular processes that are crucial for maintaining the structural integrity of cells and proper cell function. The inhibitors targeting this protein are structurally diverse and are tailored to bind with high affinity to the active or regulatory sites of CCDC147, leading to a decrease in its functional activity. These interactions are highly specific, ensuring that the inhibitors do not indiscriminately affect other proteins or pathways, which might lead to unwanted off-target effects. The design of CCDC147 inhibitors is informed by the detailed understanding of the protein's structure and its role in cellular processes, allowing for precision in targeting without influencing unrelated cellular mechanisms.
The inhibitory action of compounds against CCDC147 involves a direct or indirect modulation of the protein's activity, often through allosteric effects or by preventing post-translational modifications essential for its function. By hindering the normal functioning of CCDC147, these inhibitors can lead to a downregulation of the protein's influence on cellular infrastructure and function. The chemical inhibitors of CCDC147 may act by disrupting protein-protein interactions that are vital for the assembly of protein complexes, by altering the protein's stability, or by interfering with the signaling pathways that regulate its activity. Understanding the exact mechanism of inhibition is crucial as it allows researchers to predict the consequences of CCDC147 inhibition within the cell. These compounds are the result of rigorous biochemical research aimed at elucidating the precise function of CCDC147 and are pivotal in the study of the protein's role under normal and perturbed cellular conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K), which indirectly leads to the inhibition of CCDC147 by preventing Akt activation, a kinase that may potentially phosphorylate and regulate CCDC147. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin acts as another PI3K inhibitor. By inhibiting PI3K, it precludes the activation of downstream signaling pathways that could maintain the stability and function of CCDC147. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of the MAPK pathway. Inhibition of MEK could result in reduced activation of ERK, which may affect CCDC147's function if ERK phosphorylates this protein. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. By inhibiting p38 MAPK, SB203580 could impair any p38 MAPK-mediated phosphorylation that may regulate CCDC147's activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which may participate in signaling pathways that modulate the function of CCDC147 through phosphorylation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin selectively inhibits mTORC1, which is involved in protein synthesis and cell growth. Inhibition of mTORC1 could indirectly decrease the stability or expression of CCDC147 by reducing general protein translation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, similar to PD98059, and would inhibit the MAPK/ERK pathway potentially affecting the phosphorylation status and function of CCDC147. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is a Src family kinase inhibitor. By inhibiting Src kinases, PP2 could prevent phosphorylation events that might stabilize or activate CCDC147. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum tyrosine kinase inhibitor, which could inhibit kinases that phosphorylate and activate CCDC147, thus leading to its functional inhibition. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor, which may lead to an accumulation of misfolded proteins and induce stress responses that could indirectly affect the stability and function of CCDC147. | ||||||