CC2D2A Inhibitors
Chemical inhibitors of CC2D2A can interfere with its function in a variety of ways, as each chemical targets different aspects of the cellular pathways that are essential for the proper functioning of CC2D2A. For instance, Alsterpaullone and SB216763 both target GSK-3β, a kinase that plays a pivotal role in phosphorylating proteins within the pathways that CC2D2A operates. By inhibiting this kinase, these chemicals disrupt critical processes necessary for ciliogenesis, which is closely related to the normal function of CC2D2A. Similarly, Indirubin-3'-monoxime acts as a dual inhibitor of CDKs and GSK-3β, impeding the regulation of the cell cycle and ciliogenesis, and thereby affecting the function of CC2D2A. Roscovitine and Purvalanol A also target CDKs, which are integral in controlling cell cycle progression, a process that must be finely tuned for ciliogenesis to proceed normally, thus impacting the functionality of CC2D2A.
Additionally, Pifithrin-μ inhibits Heat Shock Protein 70 (HSP70), which assists in the proper folding and stabilization of proteins, including those involved in the pathways where CC2D2A is active. This inhibition could lead to a functional disruption of CC2D2A due to the misfolding or instability of ciliary proteins. SP600125, by inhibiting JNK, affects signaling pathways that regulate various cellular processes, including those involving CC2D2A. LY294002, a PI3K inhibitor, disrupts signaling pathways that are crucial for CC2D2A's role in ciliogenesis. Rapamycin inhibits mTOR, which is part of the pathway regulating cell growth and proliferation, processes that are crucial for ciliogenesis and thus the function of CC2D2A. Cyclopamine targets the Hedgehog signaling pathway, which is vital for ciliogenesis and the ciliary function that CC2D2A supports. Lastly, 5-Iodotubercidin and Nocodazole impact ciliogenesis by modulating cAMP levels and disrupting microtubule polymerization, respectively, both of which are essential for maintaining the structure and function of cilia, thereby influencing the function of CC2D2A.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone inhibits GSK-3β, a kinase involved in the phosphorylation of proteins related to CC2D2A's pathway. By inhibiting GSK-3β, the chemical disrupts processes that are necessary for proper ciliogenesis, thus functionally inhibiting CC2D2A which is essential for ciliary function. | ||||||
Pifithrin-μ | 64984-31-2 | sc-203195 sc-203195A | 10 mg 50 mg | $127.00 $372.00 | 4 | |
Pifithrin-μ inhibits Heat Shock Protein 70 (HSP70), which is involved in proper folding and stabilization of many proteins, including those in the ciliary pathways where CC2D2A functions. These pathways are critical for the transport and assembly of ciliary components, thus inhibition by Pifithrin-μ can lead to functional inhibition of CC2D2A. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine selectively inhibits cyclin-dependent kinases (CDKs) which are key regulators of cell cycle progression. Since ciliogenesis is closely tied to the cell cycle, and CC2D2A is a protein that is known to be involved in ciliogenesis, inhibition of CDKs by Roscovitine can lead to functional inhibition of CC2D2A. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
Indirubin-3'-monoxime is an inhibitor of CDKs and GSK-3β. It can disrupt the regulation of the cell cycle and ciliogenesis, pathways in which CC2D2A is an integral part. Through these inhibitions, Indirubin-3'-monoxime can functionally inhibit CC2D2A. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which is involved in signaling pathways that regulate various cellular processes including ciliogenesis. As CC2D2A is essential for ciliogenesis, inhibition of JNK by SP600125 can result in functional inhibition of CC2D2A. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 is a potent GSK-3β inhibitor. By inhibiting GSK-3β, SB216763 would disrupt the phosphorylation process of proteins involved in ciliogenesis, thereby functionally inhibiting CC2D2A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. As PI3K is part of signaling pathways that regulate ciliogenesis and other cellular processes where CC2D2A is involved, inhibition by LY294002 could lead to functional inhibition of CC2D2A due to disrupted signaling. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which is part of the signaling pathway that regulates cell growth and proliferation, processes that are crucial for ciliogenesis. Since CC2D2A is a ciliary protein, inhibition of mTOR by Rapamycin can lead to functional inhibition of CC2D2A. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $92.00 $204.00 | 19 | |
Cyclopamine inhibits the Hedgehog signaling pathway, which is crucial for ciliogenesis and ciliary function. Since CC2D2A is involved in forming and maintaining the ciliary structure, the inhibition by Cyclopamine can result in functional inhibition of CC2D2A. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a selective CDK inhibitor. By inhibiting CDKs, Purvalanol A can disrupt the cell cycle control and ciliogenesis. Given the role of CC2D2A in ciliogenesis, its function can be inhibited by Purvalanol A through these pathways. | ||||||