CC10 Activators
CC10 activators represent a diverse group of chemicals that have the ability to either directly or indirectly activate CC10, a crucial protein involved in anti-inflammatory responses within the respiratory epithelium. This class includes compounds such as ATRA, GW501516, 15d-PGJ2, butyrate, dexamethasone, rosiglitazone, salbutamol, 8-Bromo-cAMP, SB431542, emodin, sodium butyrate, and roflumilast, each exerting its influence through distinct mechanisms. ATRA, a derivative of vitamin A, functions as a ligand for nuclear retinoic acid receptors (RARs). Through RAR activation, ATRA modulates gene expression, influencing respiratory epithelium differentiation and activating CC10. GW501516, a PPARδ agonist, may indirectly activate CC10 by promoting an anti-inflammatory environment through PPARδ activation, modulating gene expression related to respiratory epithelial cell development.Compounds like 15d-PGJ2, a PPARγ ligand, and butyrate, an HDAC inhibitor, can influence gene expression patterns related to anti-inflammatory responses. 15d-PGJ2 binds to PPARγ, while butyrate inhibits HDAC, collectively contributing to an environment conducive to CC10 activation.
Glucocorticoids such as dexamethasone, known for their anti-inflammatory properties, activate the glucocorticoid receptor (GR), modulating gene expression in a manner supportive of CC10 activation. Similarly, rosiglitazone, a thiazolidinedione, acts as a PPARγ agonist, contributing to an anti-inflammatory state and CC10 activation. Agents like salbutamol and 8-Bromo-cAMP influence cellular processes associated with respiratory epithelial cell differentiation, activating CC10. Salbutamol, a beta-2 adrenergic receptor agonist, stimulates cAMP signaling pathways, while 8-Bromo-cAMP, a cAMP analog, directly impacts cAMP-dependent pathways. Roflumilast, a PDE4 inhibitor, increases cAMP levels, influencing downstream signaling pathways. This modulation of cAMP-dependent pathways by roflumilast may affect cellular processes related to respiratory epithelial cell differentiation, contributing to the activation of CC10 expression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA is a derivative of vitamin A and functions as a ligand for nuclear retinoic acid receptors (RARs). By binding to RARs, ATRA modulates gene expression, including genes involved in respiratory epithelium differentiation. ATRA can potentially activate CC10 by influencing the expression of genes associated with respiratory epithelial cell development. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516 is a selective agonist of peroxisome proliferator-activated receptor delta (PPARδ). Activation of PPARδ can modulate cellular processes, including anti-inflammatory responses. As CC10 is involved in anti-inflammatory activities in the lung, GW501516 may indirectly activate CC10 by promoting an anti-inflammatory environment through PPARδ activation. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $141.00 $551.00 | 5 | |
15d-PGJ2 is a naturally occurring prostaglandin found in PGD2. It acts as a ligand for PPARγ, a nuclear receptor involved in anti-inflammatory responses. By binding to PPARγ, 15d-PGJ2 can modulate gene expression related to anti-inflammatory pathways, potentially influencing CC10 expression and activity. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyrate is a short-chain fatty acid that acts as a histone deacetylase (HDAC) inhibitor. By inhibiting HDAC, butyrate can influence gene expression and chromatin remodeling. CC10 gene regulation may be affected by the epigenetic modifications induced by butyrate, leading to potential activation of CC10 expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a thiazolidinedione and an agonist for PPARγ. Activation of PPARγ by rosiglitazone can modulate gene expression related to anti-inflammatory responses. By influencing the PPARγ pathway, rosiglitazone may indirectly activate CC10 expression and contribute to an anti-inflammatory environment in the respiratory epithelium. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Salbutamol, also known as albuterol, is a beta-2 adrenergic receptor agonist. Activation of the beta-2 adrenergic receptor can stimulate cAMP signaling pathways. By modulating cAMP levels, salbutamol may influence cellular processes associated with respiratory epithelial cell differentiation, potentially leading to the activation of CC10 expression. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable analog of cyclic AMP (cAMP). It can activate protein kinase A (PKA) and influence downstream signaling pathways. By modulating cAMP-dependent pathways, 8-Bromo-cAMP may affect cellular processes related to respiratory epithelial cell differentiation, potentially leading to the activation of CC10 expression. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a selective inhibitor of the TGF-β type I receptor, blocking TGF-β signaling. TGF-β is known to play a role in epithelial-mesenchymal transition (EMT). By inhibiting TGF-β signaling, SB431542 may influence processes related to respiratory epithelial cell differentiation and potentially contribute to the activation of CC10 expression. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin is a natural anthraquinone derivative with anti-inflammatory properties. It can inhibit NF-κB signaling, a pathway involved in inflammation. By modulating NF-κB signaling, emodin may contribute to an anti-inflammatory environment in the respiratory epithelium, potentially leading to the activation of CC10, which is associated with anti-inflammatory activities in the lung. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a salt form of butyrate, is a short-chain fatty acid and an HDAC inhibitor. Similar to butyrate, sodium butyrate can influence epigenetic modifications, including histone acetylation. By inhibiting HDAC, sodium butyrate may modulate gene expression and chromatin remodeling, potentially affecting CC10 gene regulation and leading to its activation in respiratory epithelial cells. | ||||||